TABLE 2.

Univariate and Multivariate Cox Analysis of Clinicopathologic Features in H3 K27M-mt DMGs

		95% Confidence Interval				95% Confidence Interval
	Univariate Hazard Ratio	Lower	Upper	P	Multivariate Hazard Ratio	Lower	Upper	P
Age (>18 vs. ≤18 y)	0.979	0.965	0.993	0.003	0.483	0.286	0.817	0.007
Sex (male vs. female)	1.008	0.654	1.553	0.971	—	—	—	—
Anatomic location (brainstem vs. others)	0.567	0.364	0.883	0.012	0.799	0.466	1.371	0.415
Tumor diameter (>3 vs. ≤3 cm)	1.954	0.977	3.909	0.058	—	—	—	—
Dissemination (yes vs. no)	0.755	0.347	1.639	0.477	—	—	—	—
Conventional histologic grade (2/3/4)	1.954	0.977	3.909	0.303	—	—	—	—
H3.1 vs. H3.3	1.140	0.524	2.482	0.741	—	—	—	—
ATRX expression (lost vs. intact)	2.265	1.156	4.436	0.017	2.235	1.074	4.653	0.032
p53 positivity (positive vs. negative)	1.256	0.703	2.244	0.441	—	—	—	—
Ki-67 (>5% vs. ≤5%)	2.242	1.029	4.889	0.042	2.488	1.049	5.903	0.039
MGMT (methylated vs. unmethylated)	0.471	0.112	1.983	0.305

Bold P values <0.05 were considered statistically significant.