TABLE 2.
List of top 25 upregulated serum exosomal miRNAs in IS patients.
| HCs |
IS |
Tissue specificity | ||||||
| miRNA species | Log2FC | P value | 1 | 2 | 1 | 2 | Tissue | References |
| hsa-miR-9-3p | 7.15 | 4.41E-37 | 3.35 | 10.49 | 939.79 | 804.15 | brain | Landgraf et al., 2007; Guo et al., 2014; Ludwig et al., 2016 |
| hsa-miR-450b-5p | 4.15 | 5.58E-91 | 82.04 | 77.91 | 1,473.48 | 1,377.38 | n/a | |
| hsa-miR-124-3p | 3.62 | 2.55E-118 | 430.27 | 422.51 | 5,631.87 | 4,819.10 | brain | Landgraf et al., 2007; Guo et al., 2014; Ludwig et al., 2016 |
| hsa-miR-143-3p | 2.42 | 1.05E-05 | 13,541.80 | 15,502.34 | 37,232.75 | 117,740.19 | brain | Landgraf et al., 2007; Guo et al., 2014 |
| hsa-miR-30e-3p | 2.18 | 3.04E-05 | 168.26 | 254.70 | 622.18 | 1,285.71 | n/a | |
| hsa-miR-223-3p | 2.15 | 1.92E-92 | 2,664.50 | 2,445.14 | 10,988.66 | 11,711.82 | spleen | Guo et al., 2014 |
| hsa-miR-340-5p | 2.08 | 2.00E-07 | 190.86 | 305.64 | 862.27 | 1,235.82 | n/a | |
| hsa-miR-4286 | 2.01 | 1.44E-27 | 358.28 | 361.08 | 1,564.71 | 1,337.93 | n/a | |
| hsa-miR-450a-5p | 2.00 | 1.17E-21 | 180.81 | 188.78 | 775.84 | 697.39 | n/a | |
| hsa-miR-718 | 1.92 | 1.69E-28 | 226.85 | 233.73 | 862.96 | 878.42 | n/a | |
| hsa-miR-223-5p | 1.66 | 2.57E-28 | 439.48 | 480.94 | 1,417.91 | 1,479.50 | spleen | Guo et al., 2014 |
| hsa-miR-221-5p | 1.58 | 7.62E-13 | 282.10 | 239.72 | 819.06 | 741.49 | n/a | |
| hsa-miR-144-5p | 1.54 | 1.89E-05 | 282.94 | 371.56 | 753.89 | 1,141.82 | n/a | |
| hsa-let-7a-3p | 1.36 | 5.32E-19 | 782.69 | 720.66 | 2,040.78 | 1,831.10 | n/a | |
| hsa-miR-98-5p | 1.30 | 1.67E-06 | 246.11 | 305.64 | 613.26 | 746.13 | brain | Landgraf et al., 2007 |
| hsa-miR-338-5p | 1.29 | 1.32E-15 | 2,724.77 | 2,404.68 | 6,778.13 | 5,754.38 | n/a | |
| hsa-miR-4448 | 1.25 | 9.67E-42 | 3,867.41 | 3,628.75 | 9,155.73 | 8,714.53 | n/a | |
| hsa-miR-32-5p | 1.25 | 3.39E-12 | 292.15 | 275.68 | 674.32 | 679.99 | n/a | |
| hsa-miR-532-5p | 1.20 | 2.17E-03 | 549.98 | 617.28 | 953.51 | 1,722.02 | n/a | |
| hsa-miR-93-5p | 1.15 | 7.22E-05 | 1,380.38 | 1,627.09 | 2,648.56 | 4,020.75 | brain | Guo et al., 2014 |
| hsa-miR-193a-5p | 1.14 | 2.66E-09 | 909.93 | 807.55 | 2,062.05 | 1,720.86 | muscle | |
| hsa-miR-425-3p | 1.11 | 1.94E-08 | 615.27 | 575.33 | 1,402.14 | 1,162.71 | n/a | |
| hsa-miR-24-3p | 1.10 | 5.70E-13 | 1,405.49 | 1,276.50 | 3,067.69 | 2,688.62 | n/a | |
| hsa-miR-374a-5p | 1.06 | 8.23E-11 | 2,993.48 | 2,662.38 | 6,431.72 | 5,396.98 | n/a | |
| hsa-miR-4443 | 1.01 | 2.09E-06 | 738.32 | 644.25 | 1,532.47 | 1,254.38 | n/a | |
n/a, not available.