TABLE 3.

List of 20 upregulated serum exosomal miRNAs in tMCAO mice.

miRNA species	Fold change	p-value	Sham 1	Sham 2	tMCAO 1	tMCAO 2	Tissue	References
mmu-miR-124-3p	7.76	3.89E-06	0.00	0.00	78.19	59.71	brain	Lagos-Quintana et al., 2002; Landgraf et al., 2007; Guo et al., 2014; Ludwig et al., 2016
mmu-miR-9-3p	7.05	2.48E-09	1.79	1.66	261.41	194.77	brain	Lagos-Quintana et al., 2002; Landgraf et al., 2007; Guo et al., 2014; Ludwig et al., 2016
mmu-miR-668-3p	6.45	6.73E-04	0.00	0.00	31.46	24.17	n/a
mmu-miR-770-3p	6.37	8.79E-04	0.00	0.00	29.15	23.46	n/a
mmu-miR-9-5p	6.12	7.09E-14	12.56	1.66	547.34	427.93	brain	Lagos-Quintana et al., 2002; Guo et al., 2014
mmu-miR-323-3p	5.57	1.24E-03	0.00	1.66	43.95	37.67	brain	Guo et al., 2014; Ludwig et al., 2016
mmu-miR-219b-5p	5.39	2.03E-03	1.79	0.00	39.33	33.41	brain	Liang et al., 2007; Ludwig et al., 2016
mmu-miR-341-3p	4.98	6.87E-03	0.00	1.66	34.24	19.90	n/a
mmu-miR-129b-3p	4.49	1.23E-08	8.97	4.99	158.69	152.83	brain	Liang et al., 2007; Guo et al., 2014; Ludwig et al., 2016
mmu-miR-129-5p	3.82	6.73E-08	8.97	21.64	189.23	244.53	brain	Guo et al., 2014; Ludwig et al., 2016
mmu-miR-433-3p	3.43	2.40E-06	8.97	16.64	151.29	125.11	brain	Ludwig et al., 2016
mmu-miR-598-3p	3.14	2.20E-03	5.38	4.99	54.13	36.96	n/a
mmu-miR-300-3p	2.41	3.79E-03	17.94	8.32	78.65	60.42	n/a
mmu-miR-434-3p	2.25	1.06E-04	35.88	34.95	184.60	152.12	n/a
mmu-miR-107-3p	1.66	2.73E-03	145.30	83.22	397.89	321.30	n/a
mmu-miR-382-5p	1.61	5.70E-03	48.43	51.60	177.66	127.95	n/a
mmu-miR-128-3p	1.34	1.59E-03	6,709.11	9,163.98	20,672.90	19,481.50	brain	Lagos-Quintana et al., 2002; Guo et al., 2014; Ludwig et al., 2016
mmu-let-7d-5p	1.31	1.54E-03	726.52	675.73	1,889.07	1,580.93	n/a
mmu-miR-423-5p	1.12	6.68E-03	1,462.01	1,266.58	2,693.65	3,234.36	n/a
mmu-miR-328-3p	1.08	6.85E-03	832.36	888.77	1,905.73	1,738.02	n/a

n/a, not available.