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[Preprint]. 2022 May 2:rs.3.rs-1576788. [Version 1] doi: 10.21203/rs.3.rs-1576788/v1

Figure 4. CNBP inhibits SARS-CoV-2 infection in vivo.

Figure 4.

(A and B) Weight loss and survival of WT and Cnbp−/− mice intranasally infected with SARS-CoV-2 MA10 strain (1*10e5 PFUs). (C-D) WT and Cnbp−/− mice were infected intranasally with SARS-CoV-2 MA10 strain (1*10e5 PFUs) on day 1 and 2 post-infection (p.i.), the lungs were collected for qRT-PCR analysis of virus RNA levels NP(C) and NSP14 (D). (E) Viral lung titers of WT and Cnbp−/− mice at 1 and 2 days p.i. (F and G) Normalized mRNA levels of IFN-β (F) and IL12b (G) from lung samples infected with SARS-CoV-2 MA10 strain. (H and I) Representative images (H) and pathology evaluation (I) of H&E-stained lung sections from WT and Cnbp−/− mice at 4 days p.i. of SARS-CoV-2 MA10. (J-L) Flow plots (J), percentage (K) and cell number (L) of neutrophils in the lung from WT and Cnbp−/− mice at 4 days p.i.