Table 5.
Top results in Mendelian randomization analyses
| INV MR1 | |||||||
|---|---|---|---|---|---|---|---|
| Exposure | Chr | Gene type | Outcome | Beta | SE | p | N SNPs |
| PSRC1 | 1 | Protein coding | CHD | −0.084 | 0.0075 | 4.8E-29 | 7 |
| LTA | 6 | Protein coding | CHD | −0.069 | 0.011 | 1.3E-09 | 5 |
| MIR6891 | 6 | miRNA | CHD | 1.72 | 0.28 | 2.0E-09 | 25 |
| LIPA | 10 | Protein coding | CHD | 0.0033 | 0.00039 | 2.9E-17 | 18 |
| PHETA1 | 12 | Protein coding | CHD | −0.078 | 0.013 | 4.7E-09 | 3 |
| ACSL6 | 5 | Protein coding | COVID-19 | 0.19 | 0.064 | 0.0025# | 4 |
| DPP9 | 19 | Protein coding | COVID-19 | −0.044 | 0.017 | 0.0078# | 3 |
| HLA-DRB1 | 6 | Protein coding | COVID-19 | 0.00099 | 0.00018 | 1.9E-08# | 35 |
| IFNAR2 | 21 | Protein coding | COVID-19 | −0.023 | 0.0037 | 1.8E-06# | 11 |
| OAS1 | 12 | Protein coding | COVID-19 | −0.0086 | 0.0022 | 1.6E-04$ | 1 |
| SLC22A31 | 12 | Protein coding | COVID-19 | 0.32 | 0.11 | 0.0029 | 13 |
| TYK2 | 21 | Protein coding | COVID-19 | 0.011 | 0.0021 | 2.8E-08 | 3 |
| AC006460.2 | 2 | Bidirectional promoter lncRNA | SBP | −5.60 | 0.55 | 2.3E-24 | 3 |
| MAP4 | 3 | Protein coding | SBP | 0.092 | 0.0086 | 4.6E-27 | 4 |
| PHETA1 | 12 | Protein coding | SBP | −0.92 | 0.058 | 1.9E-58 | 3 |
| SLC5A11 | 16 | Protein coding | SBP | −0.82 | 0.066 | 5.3E-35 | 21 |
| ACADVL | 17 | Protein coding | SBP | −0.035 | 0.0030 | 1.5E-31 | 3 |
1,
Beta/SE and p-value were obtained by inverse variance weighted MR method.
#,
Heterogeneity was observed in MR analyses. Sensitivity analyses were performed with median-based and mode-based MR methods in Supplemental Table 9.
$,
MR analysis was performed at gene level. At splice variation level (rs10774671), the MR p = 4E-06.