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. 2022 Apr 27;10:912133. doi: 10.3389/fbioe.2022.912133

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Copyright © 2022 Tan, Wang, Chen, Liu, Ma, Ma, Wang, Zeng, Xue, Yue and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophage M1/M2 imbalance increased from progressive-stage to end-stage NONFH (A,B) Representative mIHC images of M1 (CD68⁺CD80⁺CD206^-) and M2 (CD68⁺CD80⁻CD206⁺) macrophages in sections from patients with different types NONFH in the (A) progressive stage or (B) end-stage. Scale bar, 2 μm (C) Representative mIHC images of M1 and M2 macrophages in patients with osteoarthritis. Scale bar, 2 μm (D) Comparison of M1/M2 macrophage ratios in patients with different types and stages of NONFH (E,F) Comparison of the percentages of (E) M1 and (F) M2 macrophages in patients with different types and stages of NONFH (G,H) Comparison of the numbers of (G) M1 and (H) M2 macrophages in patients with different types and stages of NONFH. *p < 0.05; **p < 0.01; ***p < 0.001.