TABLE 2.
Characteristics of Patients With Malignant Pheochromocytoma/Paraganglioma
| Patient No. | Age at Diagnosis, y | Age at Time of Enrollment, y | Initial Site(s) of Disease | Sites of Metastases | Family History of Cancer | Functional Status | Presumed Mutation |
|---|---|---|---|---|---|---|---|
|
| |||||||
| 1 | 26 | 27 | Left retroperitoneal mass | Liver, left femoral neck | Unknown | Y | SDHB |
| 2 | 64 | 64 | Right adrenal and liver masses | Lungs, liver, multiple bones | Unknown carcinoma | N | |
| 3 | 30 | 30 | Left adrenal mass, multiple lung and liver masses | Lungs and liver | No | Y | |
| 4 | 36 | 38 | Para-aortic and retroperitoneal masses | Anterior mediastinal mass, lungs, multiple bones | No | Y | SDHB or SDHD |
| 5 | 40 | 42 | Mass in bladder | Urinary bladder, ribs, liver | No | Y | SDHB |
| 6 | 38 | 39 | Left adrenal mass | Cervical lymph nodes, lungs, liver, retroperitoneal masses | Unknown | Y | |
| 7 | 27 | 42 | Organ of Zuckerkandl | Mediastinum, mesenteric and para-aortic masses, left supraclavicular lymph node | No | Y | SDHB or SDHD |
| 8 | 32 | 32 | Left abdominal mass and left supraclavicular node | Retroperitoneal masses, lungs, mediastinal mass, peripheral lymph nodes | No | Y | SDHB |
| 9 | 44 | 50 | Retroperitoneal mass | Right chest wall, left subpleural-based mass, multiple bones, cord compression | No | Y | Possible SDHB |
| 10 | 40 | 46 | Left adrenal mass | Multiple bones (shoulder, spine, hip, skull, pelvis, rib, thorax, T2, T10, and T12) and lung | No | Y | |
| 11 | 13 | 17 | Left adrenal mass | Liver and retroperitoneal mass | No | Y | |
| 12 | 6 | 25 | Left adrenal mass | Retroperitoneal mass, lungs, left skull | Several with pheochromocytoma | Y | SDHB or SDHD |
| 13 | 58 | 61 | Right adrenal mass | Lungs, retroperitoneal mass, periaortic lymph nodes, liver, spleen, multiple bones | Bladder cancer | Y | |
| 14 | 23 | 25 | Right adrenal mass | Lungs, liver, retroperitoneal mass, pelvic mass, left ischium | No | Y | |
| 15 | 43 | 46 | Lytic lesion in right hip and left adrenal mass | Pelvis and low lumbar and sacral spine | ? Sarcoma | Y | |
| 16 | 19 | 32 | Right neck mass | Right adrenal mass and abdominal mass near celiac artery | Colon cancer | Y | SDHD confirmed |
| 17 | 30 | 30 | Retroperitoneal mass | Right paratracheal mass, thoracic and lumbar spine, right supraclavicular lymph node, spinal cord compression | No | Y | SDHB or SDHD |
| 18 | 34 | 38 | Presacral mass | Paraspinal thoracic mass, multiple bones, pelvic mass | No | Y | Possible SDHB |
Y indicates yes; SDHB, succinate dehydrogenase subunit B gene; N, no; SDHD, succinate dehydrogenase subunit D gene.