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. 2022 Apr 27;13:871564. doi: 10.3389/fimmu.2022.871564

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Copyright © 2022 Li, Wang, Wang, Hou and Du

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analysis of key genes and critical modules. (A, B) Functional annotation of the hub genes in the molecular subtype modules with GO analysis (A) and KEGG pathway analysis (B). (C, D) Differences in the expression of immunosuppressive (C) and stimulator genes (D) in the CL1 and CL2 subgroups. The upper and lower ends of the boxes represented an interquartile range of values. The lines in the boxes represented the median value, and the dots showed outliers. The asterisks represented the statistical p-value (*P < 0.05; **P < 0.01; ***P < 0.001, ns, no significant).