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. 2022 Apr 27;13:860821. doi: 10.3389/fimmu.2022.860821

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Copyright © 2022 Nelson, Geha and McDonald

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IEI influencing CD4⁺ T-cell activation and differentiation. (A) Genes noted in red involved in the actin cytoskeleton and formation of the immunological synapse. (B) T-cell receptor (TCR) signaling genes influence the generation of Th2 cells and type 2 inflammation. (C) IEI associated with the IL-6-STAT3 cytokine signaling pathway.