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. 2022 Apr 27;13:873789. doi: 10.3389/fimmu.2022.873789

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Copyright © 2022 Wang, Shen, Mu, Li, Zhang, Zhang, Li, Ge, Zhu, Zhang, Chen, Xing, Zhu, Chen, Wang, Huang, Li, Xiao and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Flow diagram summarizing patient recruitment, exclusion criteria, and patient groups. Patients were divided into a T-normal group (n=22) and T-defect group (n=26) according to the criteria of CAR transgene expansion, persistence, BCA, and initial response to CAR T-cell therapy. BCA, B-cell aplasia; CR, complete remission; CRS, cytokine release syndrome; CTCAE, common terminology criteria adverse events; ddPCR, droplet digital PCR; PET/CT, positron emission tomography-computed tomography; PR, partial remission; SD, stable disease; PD, disease progression.