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. 2022 Apr 27;13:873789. doi: 10.3389/fimmu.2022.873789

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Copyright © 2022 Wang, Shen, Mu, Li, Zhang, Zhang, Li, Ge, Zhu, Zhang, Chen, Xing, Zhu, Chen, Wang, Huang, Li, Xiao and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Targeted gene panel of T-cell functions and waterfall plot of germline mutations. (A) One hundred and twenty-six target genes, including ten T-cell and CAR-T cell biology categories, were selected for the waterfall plot with T-cell grading information. Fifty genes were identical to primary genetic defects reported by the IUIS/WHO committee. (B) The top 47 mutated genes that differed between the two groups, such as TNFSF9, CD19, CARD11, UNC13D, and CX3CR1, were selected for the waterfall plot with T-cell group information. The genes were arranged according to the T cell-related gene panel in (A). Each column corresponds to a sample, and cases are ordered by the lymphoma with T-defect on the left (red bar) and with T-normal (blue bar) on the right. The types of genetic alterations are shown as different colors as shown in the legend in the upper-right corner. The counts of genetic alterations are shown as none, stars, and circles, representing once, twice, and four times person-times, respectively. CAR, chimeric antigen receptor; JAK-STAT, Janus kinase-signal transducer and activator of transcription; IL-2, interleukin-2; IUIS, International Union of Immunological Societies; TCR, T-cell receptor; WHO, World Health Organization.