Table 3.
Omics studies on blood of recurrent pregnancy loss patients and controls.
| Reference(s) | Cell model | Omics strategy | Gestational age | Samples size | Results |
|---|---|---|---|---|---|
| Quintero et al., 2017 (88) | Blood leucocytes | Genomics (Whole exome sequencing) | Before 20 weeks | RPL: 49 | Mutations in MMP10 and FGA |
| Maddirevula et al., 2020 (89) | Blood | Genomics (Whole exome sequencing) | First trimester | RPL vs PI 61 vs 14 | Homozygous variant in CCDC68, CBX3, CENPH, PABPC1L, PIF1, PLK1, and REXO4 |
| Pan et al., 2018 (90) | Blood | Genomics (Whole exome sequencing) | First trimester | RPL vs NP 5 vs 5 | The homozygous mutation in CAPS |
| Mishra et al., 2019 (91) | Blood | Epigenomics (DNA methylation chip) | Before 24 weeks | RPL vs NP 28 vs 39 | ↑ MTHFR |
| Cui et al., 2019 (92) | Blood | Proteomics (iTRAQ technology, LC-MS/MS) | 55.80 ± 5.85 days | RPL vs NP 30 vs 30 | ↓ B4DTF1, PSBG-1 |
| ↑ B4DF70 | |||||
| Wu et al., 2017 (93) | Blood | Proteomics (Antibody array assay) | First trimester | RPL vs NP 60 vs 20 | ↓ IGFBP-rp1/IGFBP-7, Dkk3, ANGPT2 |
| Li et al., 2018 (94) | Blood | Metabolomics (GC-MS, LC-MS) | Less than 10 weeks | RPL vs NP 50 vs 51 | ↑ Lactic acid |
| ↓ 5-methoxytryptamine |
MMP-10, matrix metallopeptidase 10; FGA, fibrinogen alpha chain; CCDC68, coiled-coil domain containing 68; CBX3, chromobox 3; CENPH, centromere protein H; PABPC1L, poly(A) binding protein cytoplasmic 1 like; PIF1, 5’-to-3’ DNA helicase; PLK1, polo like kinase 1; REXO4, REX4 homolog, 3’-5’ exonuclease; B4DTF1, highly similar to Pregnancy-specific beta-1-glycoprotein 9; PSBG-1, pregnancy-specific beta-1-glycoprotein 1; B4DF70, highly similar to peroxiredoxin-2; IGFBP 7, insulin-like growth factor-binding protein 7; Dkk3, dickkopf-related protein 3; ANGPT2, angiopoietin-2.
↑, upregulation; ↓, downregulation.