Table 2.
The expression proportion of immune checkpoints in thyroid carcinoma.
| Immune checkpoint | Level | Overall | ATC | PDTC | PTC | p value | Test |
|---|---|---|---|---|---|---|---|
| n = 234 | n = 22 | n = 44 | n = 168 | ||||
| PDL1 (%) | Negative | 189 (80.8) | 8 (36.4) | 30 (68.2) | 151 (89.9) | <0.001 | Fisher’s exact test |
| Weak | 15 (6.4) | 3 (13.6) | 1 (2.3) | 11 (6.5) | |||
| Moderate | 10 (4.3) | 2 (9.1) | 4 (9.1) | 4 (2.4) | |||
| Strong | 20 (8.5) | 9 (40.9) | 9 (20.5) | 2 (1.2) | |||
| PD1 (%) | Negative | 219 (93.6) | 15 (68.2) | 41 (93.2) | 163 (97.0) | <0.001 | Fisher’s exact test |
| Weak | 9 (3.8) | 2 (9.1) | 2 (4.5) | 5 (3.0) | |||
| Moderate | 3 (1.3) | 2 (9.1) | 1 (2.3) | 0 (0.0) | |||
| Strong | 3 (1.3) | 3 (13.6) | 0 (0.0) | 0 (0.0) | |||
| TIGIT (%) | Negative | 197 (84.2) | 7 (31.8) | 27 (61.4) | 163 (97.0) | <0.001 | Chi-square test |
| Weak | 26 (11.1) | 8 (36.4) | 14 (31.8) | 4 (2.4) | |||
| Moderate | 11 (4.7) | 7 (31.8) | 3 (6.8) | 1 (0.6) | |||
| LAG3 (%) | Negative | 203 (86.8) | 9 (40.9) | 37 (84.1) | 157 (93.5) | <0.001 | Fisher’s exact test |
| Weak | 23 (9.8) | 7 (31.8) | 5 (11.4) | 11 (6.5) | |||
| Moderate | 3 (1.3) | 2 (9.1) | 1 (2.3) | 0 (0.0) | |||
| Strong | 5 (2.1) | 4 (18.2) | 1 (2.3) | 0 (0.0) | |||
| VISTA (%) | Negative | 146 (62.4) | 1 (4.5) | 16 (36.4) | 129 (76.8) | <0.001 | Fisher’s exact test |
| Weak | 9 (3.8) | 0 (0.0) | 2 (4.5) | 7 (4.2) | |||
| Moderate | 21 (9.0) | 4 (18.2) | 4 (9.1) | 13 (7.7) | |||
| Strong | 58 (24.8) | 17 (77.3) | 22 (50.0) | 19 (11.3) | |||
| B7H3 (%) | Negative | 102 (43.6) | 3 (13.6) | 18 (40.9) | 81 (48.2) | 0.025 | Fisher’s exact test |
| Weak | 10 (4.3) | 1 (4.5) | 1 (2.3) | 8 (4.8) | |||
| Moderate | 14 (6.0) | 2 (9.1) | 1 (2.3) | 11 (6.5) | |||
| Strong | 108 (46.2) | 16 (72.7) | 24 (54.5) | 68 (40.5) | |||
| CTLA4 (%) | Negative | 190 (81.2) | 9 (40.9) | 27 (61.4) | 154 (91.7) | <0.001 | Fisher’s exact test |
| Weak | 31 (13.2) | 6 (27.3) | 12 (27.3) | 13 (7.7) | |||
| Moderate | 10 (4.3) | 6 (27.3) | 3 (6.8) | 1 (0.6) | |||
| Strong | 3 (1.3) | 1 (4.5) | 2 (4.5) | 0 (0.0) | |||
| BTLA (%) | Negative | 209 (89.3) | 15 (68.2) | 33 (75.0) | 161 (95.8) | <0.001 | Fisher’s exact test |
| Weak | 20 (8.5) | 5 (22.7) | 8 (18.2) | 7 (4.2) | |||
| Moderate | 2 (0.9) | 1 (4.5) | 1 (2.3) | 0 (0.0) | |||
| Strong | 3 (1.3) | 1 (4.5) | 2 (4.5) | 0 (0.0) | |||
| TIM3 (%) | Negative | 158 (67.5) | 3 (13.6) | 19 (43.2) | 136 (81.0) | <0.001 | Chi-square test |
| Weak | 41 (17.5) | 3 (13.6) | 9 (20.5) | 29 (17.3) | |||
| Moderate | 17 (7.3) | 6 (27.3) | 8 (18.2) | 3 (1.8) | |||
| Strong | 18 (7.7) | 10 (45.5) | 8 (18.2) | 0 (0.0) |