Table 2.
Phenotypic and genotypic characteristics obtained using hybrid genome assembly of four Indian MDR hypervirulent K. pneumoniae ST2096.
| Isolate ID | BA10835 | BA27935 | BP3636 | BA32040 |
|---|---|---|---|---|
| Accession numbers | CP053765–CP053770 | CP058798–CP058806 | CP053771–CP053780 | JAARNO010000001.1 to JAARNO010000005.1 |
| Meropenem MIC | 128 µg/ml | 4 µg/ml | 64 µg/ml | ≤0.5µg/ml |
| Chromosomal AMR genes | aac(6′)-lb-cr, bla SHV, bla OXA-1, fosA, dfrA1 | aac(6’)-Ib-cr, bla SHV, bla OXA-1, fosA, dfrA1 | bla SHV, fosA, dfrA1 | aac(6’)-Ib-cr, bla SHV, bla OXA-1, fosA, dfrA1 |
| Chromosomal virulence genes | fyuA, irp1, kfuABC, mrkACFJ, ybtAEPQSTUX | fyuA, irp1, kfuABC, mrkACFJ, ybtAEPQSTUX | fyuA, irp1, irp2, kfuABC, mrkABCDFHIJ, ybtAEPQSTUX | fyuA, irp1, kfuABC, mrkABCDFHIJ, ybtAEPQSTUX |
| No. of plasmids | 5 | 4 | 4 | 4 |
| IncHI1B/IncFIB (pNDM-MAR) Virulence plasmid |
aadA2, armA, bla TEM-1B, bla CTX-M-15, mphE, msrE, sul1, tetD, dfrA12 | aadA2, armA, bla TEM-1B, bla CTX-M-15 , mphE, msrE, sul1, tetD, dfrA12 | aadA2, armA, aac(6’)-Ib-cr, bla TEM-1A, bla CTX-M-15, bla OXA-1, mphE, msrE, sul1, tetD, dfrA12, dfrA14 | bla TEM-1A, bla CTX-M-15, tetD, dfrA14 |
| iucABCD, iutA, rmpA2* | iucABCD, iutA, rmpA2* | iucABCD, iutA, rmpA2* | iucABCD, iutA, rmpA2* | |
| IncFIBK-IncFIIK | catA1 | absent | No AMR gene | No AMR gene |
| ColKP3 | absent | absent | bla OXA-232 | absent |
| IncFII | aadA2, rmtB, bla NDM-5, ermB, mphA, sul1, dfrA12 | aadA2, rmtB, bla NDM-5, bla TEM-1B , ermB, mphA, sul1, dfrA12 | Absent | rmtB, bla TEM-1B, ermB, mphA |
| Other plasmids | ColRNAI | Col(BS512), ColRNAI | ColRNAI | ColRNAI |
rmpA2*, rmpA2 allele number 8 was observed which is frameshifted; MIC, minimum inhibitory concentration determined by broth microdilution; AMR, antimicrobial resistance.