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. 2022 Apr 27;13:871200. doi: 10.3389/fimmu.2022.871200

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Copyright © 2022 Papathanasiou, Scott, Trotman, Beale, Price, Huggins, Zhang, Georgakoudi and Van Dyke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visual Scar Assessment. (A) Clinical photographs 42 days after cleft lip repair surgery in rabbits treated with phosphate-buffered saline (PBS) (control) or with methyl-ester of lipoxin A₄ (LXA₄-ME) (treatment). (B) Animals treated with LXA₄-ME demonstrated reduced visual scarring scores assessed with the Modified Manchester Scar Scale (median=11.00; 25^th; 75^th percentile=10.95, 11.15) compared to animals that received only PBS (control) (median=21.75; 25^th; 75^th percentile=21.12, 22.25) (statistically significant at *P < 0.05, Mann-Whitney U test; n=4 animals/group).