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. 2022 Apr 27;13:871200. doi: 10.3389/fimmu.2022.871200

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Copyright © 2022 Papathanasiou, Scott, Trotman, Beale, Price, Huggins, Zhang, Georgakoudi and Van Dyke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microscopic examination of images of representative tissue specimens stained with hematoxylin and eosin (H&E) captured at 100x (A, C) and 400x (B, D) magnification. The scale bars represent 100 um (A, C) and 20 um (B, D). Automated quantification of inflammatory cell infiltrate with Aperio Imagescope software confirmed significant reduction of inflammatory cell density in animals treated with methyl-ester of lipoxin A₄ (LXA₄-ME) (median=4986; 25^th; 75^th percentile=4784, 5099) compared to control ones treated with PBS (median=11730, 25^th; 75^th percentile=11158, 12643) (E) (statistically significant at *P < 0.05, Mann-Whitney U test; n=4 animals/group). The averages of three regions per animal were used for analysis.