Table 1.
Prognostic value of oligoclonal bands and/or IgG index in cerebrospinal fluid in patients with radiologically isolated syndrome.
| Study | Patient characteristics | End-point | Statistical test | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|---|---|
| N (W%) | Age* (y) | Follow- up* (y) | ||||||
| Abnormal CSF | Lebrun et al. (8) | 70 (75.7) | 35.6 | 5.2 | attack | Log-rank test | n.s. | p = 0.02 # |
| Lebrun et al. (6) | 415 (86.5) | 37.2 | 6.7 | attack or progression | Cox proportional hazards models | HR 2.15 [1.40–3.31] P <0.001 |
HR 1.74 [1.07–2.85] p = 0.027 |
|
| Okuda et al. (5) | 451 (78.4) | 37.2 | 4.4–2.8 | attack or progression | Cox proportional hazards models | HR 1.78 [1.11–2.87] p =0.017 |
ns | |
| Thouvenot et al. (36) | 71 (76.1) | 38.0 | 1.3 | attack | Cox proportional hazards models | HR 2.9 [0.83–10.2] p = 0.097 |
HR 2.22 [0.57–8.59] p = 0.249 |
|
| Lebrun et al. (7) | 354 (74.6) | 38.6 | 3.8 | attack or progression | Cox proportional hazards models | HR 1.26 [0.51–3.09] p = 0.61 |
– | |
| Oligoclonal Bands | Matute-Blanch et al. (33) | 75 (73.3) |
36.6 | 2.8 | attack | Cox proportional hazards models | HR 10.31 [1.37–76.61] p = 0.024 |
HR 14.70 [1.80–120.15] p = 0.012 |
| Makhani et al. (34) | 38 (71.1) | 15.4 | 4.8–2.5 | attack | Cox proportional hazards models | not shown | HR 10.9 [1.4–86.2] p = 0.020 |
|
| Makhani et al. (35) | 61 (68.9) | 15.0 | 4.2–2.4 | attack | Cox proportional hazards models |
HR 4.1 [1.1–14.4] p = 0.03 |
HR 3.0 [1.1–8.5] p = 0.04 |
|
| Lebrun et al. (8) | 70 (75.7) | 35.6 | 5.2 | attack | Fisher’s exact test |
p = 0.69 | NA | |
| Rossi et al. (37) | 18 (50) | 29.7 | 2 | attack | Multivariate logistic regression model | not shown | OR 4.45 [0.12–154.07] p = 0.400 |
|
| Munoz et al. (20) | 15 (73.3) | 38 | 6.5 | attack or progression | Fisher’s exact test |
p = 0.200 | NA | |
| IgG index | Lebrun et al. (8) | 70 (75.7) | 35.6 | 5.2 | attack | Fisher’s exact test |
p = 0.26 | NA |
| Munoz et al. (20) | 15 (73.3) | 38 | 6.5 | attack or progression | Mann–Whitney U test | p = 0.127 | NA | |
Abnormal CSF was defined as IgG index positive (>0.7) and/or the presence of OCBs (≥2). All adult patients fulfilled Okuda’s criteria, children RIS-Ped criteria. *Mean or Median value in years. #significant only among patients with ≥9 T2 lesions on MRI. P-values <0.005 are in bold [95% confidence interval]. N, total number of patients included; W%, percentage of women; HR, hazard ratio; OR, odds ratio; n.s., not significant.