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. 2022 Apr 27;13:840976. doi: 10.3389/fimmu.2022.840976

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Copyright © 2022 Vijayan, Cross, Curtis, Van Rompay, Pollara, Fox, Tomai, Hanke, Fouda, Hudgens, Permar and De Paris

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in plasma cytokine concentrations post vaccination. Plasma cytokine concentrations for IFN-a, IL-6, IL-18, IFN-g, MCP-1, and IL-1RA on day 0 (vaccine prime; grey circles) and on days 1 (filled circles) and day 3 (open circles) post vaccination for Group 1 (orange circles) and Group 2 (blue circles) animals. Note that D0 includes animals from both Group 1 and Group 2. Horizontal lines represent median values. Data between two time points were compared by Mann-Whitney test with *, **, ***, **** indicating p<0.05, p<0.01, p<0.001, or p<0.0001 respectively.