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. 2022 Apr 27;13:840976. doi: 10.3389/fimmu.2022.840976

Table 2.

Correlation of early gene expression with vaccine-induced Env-specific IgG.

Parameter Spearman Correlation
week 14 week 20 week 32 week 34
r p q r p q r p q r p q
D1 DEG
SERPING1 0.3464 0.2061 0.6314 0.0250 0.9336 0.9682 0.4536 0.0915 0.5484 0.3393 0.2161 0.6415
C3AR1 0.5321 0.0438 0.5158 0.3607 0.1870 0.6212 0.5964 0.0213 0.5158 0.3821 0.1607 0.6147
IL1RN 0.4036 0.1370 0.5932 0.1500 0.5934 0.8379 0.4286 0.1127 0.5771 0.3714 0.1735 0.6182
TNFAIP6 0.4679 0.0808 0.5470 0.1893 0.4983 0.7907 0.3607 0.1870 0.6212 0.4643 0.0834 0.5470
PLAUR -0.0750 0.7925 0.9346 -0.1857 0.5067 0.7907 -0.1357 0.6297 0.8695 -0.0107 0.9744 0.9907
FPR2 0.5071 0.0562 0.5158 0.2107 0.4498 0.7820 0.4071 0.1334 0.5900 0.4464 0.0972 0.5625
SOCS3 0.4893 0.0666 0.5318 0.2571 0.3538 0.7378 0.5000 0.0602 0.5158 0.3107 0.2592 0.6848
OAS1 0.3571 0.1917 0.6278 0.0821 0.7728 0.9263 0.3071 0.2649 0.6973 0.3607 0.1870 0.6213
TNFSF10 0.4929 0.0644 0.5207 0.3000 0.2767 0.6999 0.6786 0.0068 0.4927 0.4071 0.1334 0.5900
CCR1 0.4000 0.1408 0.5999 0.0143 0.9642 0.9833 0.2107 0.4498 0.7820 0.4357 0.1063 0.5737
LILRA3 0.6036 0.0195 0.5158 0.3500 0.2012 0.6314 0.5214 0.0488 0.5158 0.5393 0.0406 0.5158
IFITM1 0.5321 0.0438 0.5158 0.2536 0.3607 0.7379 0.6036 0.0195 0.5158 0.4607 0.0861 0.5470
ARG2 0.4821 0.0711 0.5358 0.1821 0.5150 0.7960 0.3929 0.1485 0.6004 0.3964 0.1446 0.6003
CD82 0.4179 0.1227 0.5900 0.2107 0.4498 0.7820 0.3464 0.2061 0.6313 0.2321 0.4039 0.7633
IRF7 0.5607 0.0322 0.5158 0.2500 0.3677 0.7433 0.4429 0.1002 0.5650 0.5107 0.0543 0.5158
IFI35 0.2607 0.3469 0.7378 -0.2250 0.4189 0.7633 0.0357 0.9031 0.9557 0.2964 0.2827 0.6999
NFKBIA 0.4429 0.1002 0.5650 0.1571 0.5756 0.8341 0.3750 0.1692 0.6169 0.3571 0.1917 0.6277
CSF3R 0.5500 0.0362 0.5158 0.2250 0.4189 0.7633 0.4357 0.1063 0.5737 0.5071 0.0562 0.5158
DDIT3 0.5214 0.0488 0.5158 0.2036 0.4657 0.7881 0.3000 0.2767 0.6999 0.5607 0.0322 0.5158
GP1BB 0.2036 0.4657 0.7881 0.1143 0.6858 0.8988 0.1500 0.5934 0.8379 0.2607 0.3469 0.7378
CLU 0.0786 0.7827 0.9263 0.0357 0.9031 0.9557 0.1857 0.5067 0.7907 0.0464 0.8726 0.9547
TNFAIP3 0.5107 0.0543 0.5158 0.2036 0.4657 0.7810 0.3964 0.1446 0.6003 0.4107 0.1297 0.5900
IL1RL1 0.3643 0.1824 0.6212 -0.0750 0.7925 0.9346 0.3107 0.2592 0.6848 0.4786 0.0735 0.5358
HLA-DMA -0.2607 0.3469 0.7378 0.1000 0.7208 0.9098 -0.2214 0.4266 0.7633 -0.2143 0.4407 0.7785
KIT -0.1000 0.7241 0.9098 -0.3214 0.2424 0.6804 -0.1464 0.6024 0.8473 0.1000 0.7241 0.9098
D1 Shared Pathway Genes c
IL2RA 0.3429 0.2111 0.6408 0.1179 0.6763 0.8933 0.2357 0.3966 0.7633 0.2179 0.4342 0.7750
CSF2RB 0.4821 0.0711 0.5358 0.2214 0.4266 0.7633 0.5036 0.0582 0.5158 0.4071 0.1333 0.5900
FCGR1A 0.2071 0.4578 0.7876 0.2821 0.3074 0.7138 0.2893 0.2949 0.7046 0.1857 0.5067 0.7907
DUSP4 -0.0464 0.8764 0.9547 0.1429 0.6115 0.8548 0.1821 0.5151 0.7960 -0.0786 0.7827 0.9262
HLA-DQB1 -0.5714 0.0286 0.5158 -0.3464 0.2061 0.6314 -0.6036 0.0195 0.5158 -0.4107 0.1297 0.5900
HLA-DRB1 0.1000 0.7241 0.9098 0.1071 0.7041 0.9060 0.2393 0.3892 0.7592 0.0393 0.8929 0.9547
D1 Cytokine Genes d
IFNA2 -0.1857 0.5067 0.7906 -0.2714 0.3269 0.7335 -0.2429 0.3820 0.7548 -0.0036 0.9948 0.9999
IL6 -0.0321 0.9132 0.9558 -0.0857 0.7630 0.9220 -0.0250 0.9336 0.9682 0.0321 0.9132 0.9557
IL18 0.1964 0.4819 0.7881 -0.1036 0.7144 0.9098 0.2321 0.4039 0.7633 0.1786 0.5235 0.7960
IFNG -0.3536 0.1964 0.6314 -0.3250 0.2370 0.6739 -0.1857 0.5067 0.7907 -0.2750 0.3203 0.7310
MCP1 0.0786 0.7827 0.9262 -0.0786 0.7827 0.9262 -0.1179 0.6763 0.8933 0.1179 0.6763 0.8933
D1 Cytokine Proteins
IFN-α -0.3750 0.1692 0.6169 -0.1214 0.6669 0.8932 -0.3464 0.2061 0.6314 -0.2571 0.3538 0.7378
IL-6 -0.4540 0.0905 0.5470 -0.3843 0.1573 0.6147 -0.5290 0.0447 0.5158 -0.5827 0.0248 0.5158
IL-18 -0.2643 0.3402 0.7378 -0.2643 0.3402 0.7378 -0.3107 0.2592 0.6848 -0.2393 0.3892 0.7592
IFN-γ -0.2073 0.4553 0.7873 -0.2288 0.4090 0.7633 -0.0447 0.8753 0.9547 -0.0840 0.7654 0.9220
MCP-1 -0.2321 0.4039 0.7633 -0.3214 0.2425 0.6804 0.0036 0.9948 0.1000 -0.4786 0.0734 0.5358
IL-1RA 0.1786 0.5235 0.7960 -0.1607 0.5667 0.8284 -0.0429 0.8828 0.9547 0.1214 0.6669 0.8932
D3 DEG
CLU -0.2396 0.4086 0.7633 0.0418 0.8915 0.9547 -0.4198 0.1368 0.5932 -0.2263 0.4356 0.7753
GP1BB -0.2835 0.3253 0.7335 0.1165 0.6930 0.9029 -0.4286 0.1281 0.5900 -0.2440 0.3998 0.7633
BCL2L1 -0.0637 0.8319 0.9451 0.5472 0.0458 0.5158 0.2659 0.3573 0.7378 -0.1472 0.6158 0.8590
IL1RL1 -0.5297 0.0544 0.5158 -0.1956 0.5022 0.7907 -0.1165 0.6930 0.9029 -0.6483 0.0144 0.5158
ILR2 -0.2967 0.3026 0.7047 -0.2483 0.3911 0.7606 -0.0549 0.8557 0.9506 -0.4374 0.1198 0.5900
D3 Shared Pathway Genes
HLA-C -0.1253 0.6706 0.8933 -0.2615 0.3656 0.7433 -0.2747 0.3411 0.7378 0.2396 0.4086 0.7633
FCGR1A -0.2527 0.3825 0.7548 -0.0637 0.8319 0.9451 0.1033 0.7270 0.9101 -0.2703 0.3492 0.7378
D3 Cytokine Genes
IFNA2 -0.4330 0.1239 0.5900 -0.4154 0.1412 0.5999 0.0242 0.9396 0.9729 -0.3670 0.1973 0.6314
IL6 -0.2044 0.4827 0.7881 -0.0769 0.7965 0.9360 0.0593 0.8438 0.9484 -0.2044 0.4827 0.7881
IL18 -0.7231 0.0047 0.4927 -0.4725 0.0905 0.5470 -0.2703 0.3492 0.7378 -0.6879 0.0082 0.4927
IFNG -0.3978 0.1602 0.6147 -0.1516 0.6051 0.8494 -0.0461 0.8795 0.9547 -0.4725 0.0905 0.5470
MCP1 -0.5516 0.0438 0.5158 -0.2747 0.3411 0.7378 -0.2176 0.4541 0.7873 -0.6000 0.0261 0.5158
IL1RN -0.3714 0.1918 0.6277 0.1121 0.7043 0.9060 -0.0989 0.7385 0.9136. -0.2352 0.4175 0.7633
D3 Cytokine Proteins
IFN-α -0.0632 0.8382 0.9484 0.1348 0.6589 0.8896 0.3026 0.3121 0.7212 0.2944 0.3264 0.7335
IL-6 0.3232 0.2949 0.7046 -0.0961 0.7564 0.9211 0.0874 0.7820 0.9263 0.3319 0.2820 0.6999
IL-18 -0.0660 0.8231 0.9451 0.2552 0.3757 0.7526 0.1694 0.5597 0.8284 -0.1012 0.7298 0.9117
IFN-γ -0.3160 0.2689 0.6988 -0.0022 0.9968 0.1000 0.3005 0.2870 0.7021 -0.0354 0.9062 0.9557
MCP-1 -0.7890 0.0013 0.4228 -0.2835 0.3253 0.7335 0.2527 0.3825 0.7548 -0.5165 0.0615 0.5158
IL-1RA 0.0399 0.8967 0.9556 -0.0446 0.8839 0.9547 0.1948 0.5030 0.7907 0.1338 0.6483 0.8824
a

bold font corresponds to p<0.05.

b

bold and italic font corresponds to p<0.01

c

Genes shared between the top five scoring pathways on D1 also included IL1RN, SOCS3, IFITM1, IRF7, NFKBIA, and KIT, genes that are included in the DEG.

d

The gene encoding IL-1RA is ILRN that is included in the DEG.