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. 2022 Apr 27;13:840976. doi: 10.3389/fimmu.2022.840976

Table 4.

Correlation of early gene expression with vaccine-induced Env-specific ADCC.

Parameter Spearman Correlation
week 14 week 20 week 32 week 34
r p q r p q r p q r p q
D1 DEG
SERPING1 -0.0464 0.8726 0.9547 0.0964 0.7337 0.9117 0.2679 0.3334 0.7378 0.4684 0.0799 0.5470
C3AR1 a -0.0893 0.7532 0.9189 0.3929 0.1485 0.6004 0.2964 0.2827 0.6999 0.6363 0.0129 0.5121
IL1RN b -0.0071 0.9847 0.9981 0.3179 0.2479 0.6804 0.4321 0.1094 0.5737 0.6768 0.0073 0.4927
TNFAIP6 0.1571 0.5756 0.8342 0.1214 0.6669 0.8932 0.1393 0.6205 0.8621 0.5016 0.0590 0.5158
PLAUR -0.3714 0.1735 0.6182 0.0607 0.8324 0.9450 0.0214 0.9438 0.9758 0.3689 0.1751 0.6184
FPR2 0.1071 0.7049 0.9060 0.1143 0.6858 0.8988 0.1786 0.5253 0.7960 0.3947 0.1453 0.6003
SOCS3 0.3000 0.2767 0.6999 0.5429 0.0391 0.5158 0.7393 0.0023 0.4664 0.5275 0.0458 0.5158
OAS1 0.1286 0.6482 0.8824 0.0357 0.9031 0.9557 0.1571 0.5756 0.8342 0.4316 0.1091 0.5737
TNFSF10 -0.0393 0.8929 0.9547 0.3679 0.1779 0.6212 0.4571 0.0888 0.5470 0.5699 0.0292 0.5158
CCR1 0.2857 0.3012 0.7047 0.2143 0.4421 0.7785 0.3500 0.2012. 0.6314 0.6436 0.0117 0.4927
LILRA3 0.2000 0.4738 0.7881 0.2929 0.2888 0.7021 0.2786 0.3139 0.7212 0.4980 0.0611 0.5158
IFITM1 0.2750 0.3203 0.7310 0.2286. 0.4114 0.7633 0.3393 0.2161 0.6415 0.4832 0.0700 0.5358
ARG2 0.2679 0.3335 0.7378 0.1500 0.5934 0.8379 0.2571 0.3538 0.7378 0.3523 0.1964 0.6314
CD82 0.1750 0.5320 0.8022 0.1607 0.5667 0.8284 0.2857 0.3012 0.7047 0.3043 0.2673 0.6979
IRF7 0.2929 0.2888 0.7021 0.2214 0.4266 0.7633 0.3286 0.2317 0.6722 0.5662 0.0304 0.5158
IFI35 0.2250 0.4189 0.7633 0.0607 0.8324 0.9451 0.2250 0.4189 0.7633 0.4057 0.1336 0.5900
NFKBIA 0.1393 0.6205 0.8621 0.0571 0.8425 0.9484 0.1929 0.4901 0.7907 0.4131 0.1263 0.5900
CSF3R 0.2786 0.3139 0.7212 0.1643 0.5580 0.8283 0.2643 0.3401 0.7378 0.5348 0.0425 0.5158
DDIT3 0.0893 0.7532 0.9189 0.1786 0.5253 0.7960 0.1286 0.6482 0.8824 0.5275 0.0458 0.5158
GP1BB 0.0036 0.9949 0.9999 -0.2464 0.3748 0.7526 -0.2929 0.2888 0.7021 0.0664 0.0814 0.9444
CLU -0.0786 0.7827 0.9263 -0.3286 0.2317 0.6723 -0.1750 0.5320 0.8022 -0.0646 0.8187 0.9451
TNFAIP3 -0.0250 0.9336 0.9682 0.3500 0.2012 0.6314 0.4286 0.1127 0.5771 0.6584 0.0096 0.4927
IL1RL1 -0.0536 0.8505 0.9506 -0.1357 0.6297 0.8695 -0.1179 0.6763 0.8933 0.4186 0.1209 0.5900
HLA-DMA -0.5071 0.0562 0.5158 -0.3143 0.2536 0.6848 -0.5607 0.0322 0.5158 -0.3025 0.2703 0.6988
KIT -0.3250 0.2370 0.6739 -0.2143 0.4421 0.7785 -0.3036 0.2708 0.6988 0.1778 0.5239 0.7960
D1 Shared Pathway Genes c
IL2RA 0.3357 0.2212 0.6510 0.4571 0.0888 0.5470 0.5607 0.0322 0.5158 0.5496 0.0364 0.5158
CSF2RB 0.1286 0.6482 0.8824 0.2964 0.2827 0.6999 0.4321 0.1094 0.5737 0.5939 0.0221 0.5158
FCGR1A -0.1964 0.4819 0.7880 0.5571 0.0335 0.5158 0.3393 0.2161 0.6414 0.5625 0.0317 0.5158
DUSP4 -0.4714 0.0783 0.5470 0.2036 0.4657 0.7881 0.3107 0.2592 0.6848 0.3799 0.1618 0.6147
HLA-DQB1 -0.4964 0.0623 0.5158 -0.3179 0.2479 0.6804 -0.4357 0.1063 0.5737 -0.3596 0.1867 0.6212
HLA-DRB1 -0.2429 0.3820 0.7548 -0.1500 0.5934 0.8379 -0.3000 0.2767 0.6999 -0.0922 0.7421 0.9136
D1 Cytokine Genes d
IFNA2 -0.1678 0.5492 0.8226 0.0536 0.8525 0.9506 0.0856 0.7630 0.9220 0.2545 0.3561 0.7378
IL6 -0.4036 0.1370 0.5931 -0.0250 0.9336 0.9682 -0.0321 0.9132 0.9557 0.3043 0.2673 0.6979
IL18 -0.4214 0.1193 0.5900 -0.2250 0.4189 0.7633 -0.1036 0.7144 0.9098 0.2102 0.4478 0.7820
IFNG -0.5500 0.0362 0.5158 -0.2643 0.3402 0.7378 -0.1643 0.5579 0.8283 -0.0387 0.8917 0.9550
MCP1 -0.1500 0.5934 0.8379 0.5179 0.0506 0.5158 0.3786 0.1649 0.6147 0.6621 0.0091 0.4927
D1 Cytokine Proteins
IFN-α -0.0714 0.8025 0.9365 -0.0714 0.8025 0.9365 -0.3536 0.1964 0.6313 0.0590 0.8342 0.9455
IL-6 0.1144 0.6829 0.8984 -0.1001 0.7212 0.9098 -0.0536 0.8497 0.9506 -0.3840 0.1567 0.6147
IL-18 0.2214 0.4266 0.7633 -0.0893 0.7532 0.9188 -0.2214 0.4266 0.7633 0.0387 0.8917 0.9547
IFN-γ 0.1001 0.7213 0.9098 -0.0572 0.8396 0.9484 -0.0947 0.7361 0.9130 0.0406 0.8849 0.9547
MCP-1 0.1036 0.7144 0.9098 -0.0786 0.7827 0.9262 0.2536 0.3607 0.7379 -0.1070 0.7021 0.9060
IL-1RA 0.1964 0.4819 0.7881 -0.1500 0.5934 0.8379 -0.1321 0.6389 0.8785 0.1180 0.6726 0.8933
D3 DEG
CLU 0.1121 0.7043 0.9036 -0.3275 0.2530 0.6906 -0.5736 0.0349 0.5243 -0.2978 0.2981 0.7089
GP1BB 0.0549 0.8557 0.9504 -0.1692 0.5629 0.8312 -0.5033 0.0694 0.5446 -0.2556 0.3742 0.7604
BCL2L1 -0.2528 0.3825 0.7650 -0.0330 0.9155 0.9565 -0.1429 0.6266 0.8651 -0.0133 0.9663 0.9836
IL1RL1 -0.3143 0.2735 0.7036 -0.1560 0.5944 0.8376 0.1253 0.6706 0.8904 -0.3911 0.1663 0.9196
ILR2 -0.1604 0.5838 0.8376 -0.2967 0.3025 0.7089 0.0637 0.8319 0.9446 -0.3400 0.2324 0.6774
D3 Shared Pathway Genes
HLA-C 0.1033 0.7270 0.9115 0.1868 0.5221 0.7999 -0.0637 0.8319 0.9446 0.1978 0.4942 0.7962
FCGR1A -0.2351 0.4174 0.7633 -0.1076 0.7156 0.9098 0.2307 0.4265 0.7633 0.0422 0.8870 0.9547
D3 Cytokine Genes
IFNA2 -0.3802 0.1808 0.6282 -0.5209 0.0591 0.5243 0.0066 0.9879 0.9982 -0.4422 0.1144 0.5820
IL6 -0.2835 0.3253 0.7382 -0.2088 0.4731 0.7933 -0.0637 0.8319 0.9446 -0.3022 0.2907 0.7081
IL18 -0.6352 0.0171 0.5243 -0.2659 0.3573 0.7453 -0.7534 0.0028 0.4741 -0.7231 0.0047 0.5001
IFNG -0.3758 0.1862 0.6282 -0.1604 0.5838 0.8376 0.2044 0.4827 0.7933 -0.5111 0.0641 0.5292
MCP1 -0.2044 0.4827 0.7933 0.2967 0.3025 0.7089 0.6176 0.0212 0.5243 0.0333 0.9114 0.9565
IL1RN -0.1780 0.5423 0.8183 0.0593 0.8438 0.9480 0.1912 0.5121 0.7999 -0.0022 0.9970 0.9999
D3 Cytokine Proteins
IFN-α -0.2063 0.4958 0.7962 0.1183 0.6991 0.9036 0.1898 0.5316 0.8063 0.1936 0.5224 0.7999
IL-6 0.1922 0.5513 0.8281 -0.0437 0.8974 0.9563 -0.0874 0.7821 0.9235 -0.0133 0.9615 0.9830
IL-18 -0.0968 0.7413 0.9152 -0.1298 0.6562 0.8862 0.0484 0.8707 0.9552 -0.0645 0.8521 0.9446
IFN-γ -0.3624 0.2021 0.6388 -0.1658 0.5684 0.8318 0.0685 0.8159 0.9432 0.0391 0.8935 0.9552
MCP-1 -0.5692 0.0366 0.5243 -0.2659 0.3573 0.7453 -0.0462 0.8796 0.9552 -0.3845 0.1741 0.6217
IL-1RA 0.1009 0.7327 0.9131 -0.2229 0.4417 0.7872 -0.0211 0.9482 0.9759 0.0427 0.8856 0.9552
a

bold font corresponds to p < 0.05.

b

bold and italic font corresponds to p < 0.01.

c

Genes shared between the top five scoring pathways on D1 also included IL1RN, SOCS3, IFITM1, IRF7, NFKBIA, and KIT, genes that are included in the DEG.

d

The gene encoding IL-1RA is ILRN that is included in the DEG.