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. 2022 Apr 27;13:840976. doi: 10.3389/fimmu.2022.840976

Table 5.

Correlation of early gene expression with follicular T helper cells (TFH) or with memory or germinal center (GC) B cells (week 34).

Parameter Spearman Correlation
PBMC Lymph Nodes
Memory B cells Memory B cells GC B cells Env-specific TFH
r p q r p q r p q r p q
D1 DEG
SERPING1 a ,b 0.3914 0.1492 0.7379 0.1464 0.6024 0.8743 0.6214 0.0155 0.3200 0.6536 0.0099 0.3200
C3AR1 0.1487 0.5209 0.8529 0.1036 0.7144 0.9287 0.3393 0.2161 0.7714 0.5429 0.0391 0.4579
IL1RN 0.3968 0.1432 0.7379 0.2679 0.3334 0.7868 0.5286 0.0454 0.4825 0.7286 0.0029 0.3153
TNFAIP6 0.1877 0.5002 0.8523 0.2821 0.3074 0.7861 0.4107 0.1297 0.7202 0.7143 0.0037 0.3153
PLAUR 0.2735 0.3216 0.7861 0.1571 0.5756 0.8658 0.6286 0.0141 0.3200 0.5393 0.0406 0.4578
FPR2 0.2413 0.3835 0.8163 0.3107 0.2592 0.7714 0.3643 0.1824 0.7458 0.6500 0.0105 0.3200
SOCS3 0.5594 0.0324 0.4578 0.3429 0.2111 0.7714 0.3107 0.2592 0.7714 0.3857 0.1566 0.7379
OAS1 0.3021 0.2719 0.7729 0.2929 0.2888 0.7729 0.4357 0.1063 0.6703 0.7643 0.0014 0.3153
TNFSF10 0.4004 0.1394 0.7378 0.2964 0.2827 0.7729 0.4000 0.1408 0.7378 0.5679 0.0297 0.4426
CCR1 0.2520 0.3622 0.8163 0.3750 0.1692 0.7379 0.4214 0.1193 0.6857 0.6250 0.0148 0.3200
LILRA3 0.1859 0.5041 0.8523 0.3571 0.1917 0.7667 0.3107 0.2592 0.7714 0.5429 0.0391 0.4578
IFITM1 0.1680 0.5466 0.8543 0.0143 0.9642 0.9907 0.1714 0.5406 0.8529 0.3500 0.2012 0.7714
ARG2 0.2806 0.3087 0.7861 0.2464 0.3748 0.8163 0.3107 0.2592 0.7714 0.5393 0.0462 0.4578
CD82 0.3682 0.1763 0.7379 0.2714 0.3269 0.7861 0.3250 0.2370 0.7714 0.6214 0.0155 0.3200
IRF7 0.1930 0.4875 0.8512 0.2321 0.4039 0.8167 0.2750 0.3203 0.7861 0.5714 0.0286 0.4426
IFI35 0.3682 0.1763 0.7379 0.2143 0.4421 0.8367 0.5393 0.0406 0.4578 0.5250 0.0471 0.4864
NFKBIA 0.2520 0.3621 0.8163 0.1964 0.4819 0.8512 0.3679 0.1779 0.7379 0.6893 0.0057 0.3166
CSF3R 0.1180 0.6735 0.9054 0.2393 0.3892 0.8163 0.3393 0.2161 0.7714 0.5500 0.0362 0.4578
DDIT3 0.1662 0.5512 0.8544 0.2714 0.3268 0.7861 0.3321 0.2264 0.7714 0.7071 0.0042 0.3153
GP1BB 0.1019 0.7167 0.9287 0.3071 0.2649 0.7729 0.3536 0.1964 0.7714 0.6571 0.0094 0.3200
CLU 0.1948 0.4837 0.8512 0.1750 0.5320 0.8529 0.4214 0.1193 0.6857 0.4500 0.0944 0.6415
TNFAIP3 0.3342 0.2221 0.7714 0.2857 0.3012 0.7861 0.4536 0.0915 0.6415 0.7214 0.0033 0.3135
IL1RL1 -0.0858 0.7602 0.9302 0.0500 0.8626 0.9550 0.6786 0.0068 0.3166 0.4607 0.0861 0.6415
HLA-DMA -0.5719 0.0281 0.4426 -0.0179 0.9540 0.9907 -0.3036 0.2708 0.7729 -0.0929 0.7435 0.9202
KIT 0.0393 0.8901 0.9709 0.0607 0.8324 0.9483 0.5714 0.0286 0.4426 0.4571 0.0888 0.6415
D1 Shared Pathway Genes c
IL2RA 0.4021 0.1377 0.7378 0.2393 0.3892 0.8163 0.2107 0.4498 0.8367 0.3000 0.2767 0.7729
CSF2RB 0.3181 0.2461 0.7714 0.2929 0.2888 0.7729 0.3893 0.1525 0.7379 0.5929 0.0222 0.3933
FCGR1A 0.4629 0.0838 0.6414 0.3179 0.2479 0.7714 0.3821 0.1607 0.7379 0.4893 0.0666 0.5629
DUSP4 0.0626 0.8249 0.9483 0.2143 0.4421 0.8367 0.4250 0.1159 0.6857 0.1821 0.5150 0.8529
HLA-DQB1 -0.2270 0.4130 0.8189 -0.1929 0.4901 0.8512 -0.1464 0.6023 0.8743 -0.1786 0.5235 0.8529
HLA-DRB1 -0.4147 0.1249 0.7038 -0.2821 0.3074 0.7861 -0.3250 0.2370 0.7714 -0.0036 0.9948 0.9969
D1 Cytokine Genes d
IFNA2 0.3682 0.1763 0.7379 0.1929 0.4901 0.8512 0.5179 0.0506 0.4951 0.3250 0.2370 0.7714
IL6 0.2967 0.2807 0.7729 0.2500 0.3678 0.8163 0.5536 0.0349 0.4578 0.6857 0.0061 0.3166
IL18 -0.1948 0.4837 0.8512 -0.2857 0.3011 0.7861 0.5107 0.0543 0.5031 0.1964 0.4819 0.8512
IFNG 0.1537 0.5817 0.8658 -0.2429 0.3820 0.8163 0.4679 0.0808 0.6399 0.2107 0.4498 0.8367
MCP1 0.5326 0.0431 0.4716 0.3750 0.1692 0.7379 0.5179 0.0506 0.4951 0.6393 0.0122 0.3201
D1 Cytokine Proteins
IFN-α -0.1716 0.5380 0.8529 -0.0929 0.7435 0.9302 -0.2750 0.3203 0.7861 0.1464 0.6023 0.8743
IL-6 0.3399 0.2132 0.7714 -0.5076 0.0554 0.5031 -0.4486 0.0948 0.6415 -0.0286 0.9206 0.9871
IL-18 0.1287 0.6455 0.8959 0.0571 0.8425 0.9483 -0.1000 0.7241 0.9287 0.4071 0.1334 0.7295
IFN-γ 0.2952 0.2820 0.7729 -0.2324 0.4016 0.8166 -0.0840 0.7539 0.9302 0.2717 0.3246 0.7861
MCP-1 0.5094 0.0545 0.5031 -0.2286 0.4114 0.8189 0.0571 0.8425 0.9483 0.3357 0.2212 0.7714
IL-1RA -0.0197 0.9465 0.9907 0.0786 0.7827 0.9414 0.2250 0.4189 0.8212 0.4429 0.1002 0.6657
D3 DEG
CLU 0.1342 0.6452 0.8881 0.4374 0.1198 0.6852 0.0044 0.9911 0.9966 0.1516 0.6051 0.8703
GP1BB 0.0528 0.8587 0.9582 0.4549 0.1044 0.6588 -0.0902 0.7582 0.9305 0.1385 0.6375 0.8872
BCL2L1 0.3410 0.2313 0.7550 0.5209 0.0591 0.8463 0.1782 0.5391 0.8463 0.4769 0.0872 0.6249
IL1RL1 0.2464 0.3929 0.7988 -0.1956 0.5022 0.8424 0.2926 0.3074 0.7734 -0.2440 0.3998 0.7988
ILR2 -0.1276 0.6622 0.8979 -0.1604 0.5838 0.8616 0.0946 0.7467 0.9305 -0.2440 0.3998 0.7988
D3 Shared Pathway Genes
HLA-C -0.0990 0.7352 0.9305 0.0637 0.8319 0.9532 -0.2332 0.4194 0.8037 0.0593 0.8438 0.9532
FCGR1A 0.3850 0.1736 0.7180 0.0374 0.9035 0.9842 0.4158 0.1396 0.7180 -0.0330 0.9155 0.9911
D3 Cytokine Genes
IFNA2 0.1210 0.6784 0.9030 -0.2747 0.3411 0.7803 0.4422 0.1143 0.6852 0.0242 0.9396 0.9911
IL6 0.3256 0.2543 0.7550 -0.1077 0.7126 0.9288 0.2794 0.3305 0.7741 0.1780 0.5423 0.8463
IL18 0.1716 0.5549 0.8498 -0.3890 0.1703 0.7180 0.1496 0.6076 0.8703 -0.1956 0.5022 0.8424
IFNG 0.0616 0.8349 0.9532 -0.3363 0.2399 0.7550 -0.0572 0.8468 0.9536 -0.1780 0.5423 0.8463
MCP1 0.6161 0.0213 0.3870 -0.0154 0.9638 0.9911 0.2444 0.3969 0.7988 0.0418 0.8915 0.9769
IL1RN 0.3476 0.2222 0.7550 0.2528 0.3825 0.7988 -0.0946 0.7466 0.9305 -0.0198 0.9517 0.9911
D3 Cytokine Proteins
IFN-α -0.2672 0.3737 0.7988 0.0908 0.7678 0.9332 -0.3444 0.2477 0.7550 0.1513 0.6196 0.8824
IL-6 -0.1706 0.5833 0.8616 -0.5154 0.0769 0.6185 0.0088 0.9872 0.9953 -0.4193 0.1666 0.7180
IL-18 0.1828 0.5262 0.8463 0.4004 0.1561 0.7180 -0.0903 0.7579 0.9305 0.3476 0.2221 0.7550
IFN-γ 0.2500 0.3846 0.7988 0.1503 0.6059 0.8703 0.1018 0.7291 0.9288 0.1635 0.5740 0.8616
MCP-1 0.0792 0.7878 0.9412 -0.0637 0.8319 0.9532 -0.1254 0.6673 0.8979 0.0286 0.9276 0.9911
IL-1RA 0.3195 0.2622 0.7550 0.4577 0.1022 0.6565 0.2350 0.4139 0.8014 0.4858 0.0811 0.6185
a

bold font corresponds to p < 0.05.

b

bold and italic font corresponds to p < 0.01.

c

Genes shared between the top five scoring pathways on D1 also included IL1RN, SOCS3, IFITM1, IRF7, NFKBIA, and KIT, genes that are included in the DEG.

d

The gene encoding IL-1RA is ILRN that is included in the DEG.