Skip to main content
. 2022 Apr 27;13:840976. doi: 10.3389/fimmu.2022.840976

Table 6.

Correlation of early gene expression with antigen-specific CD8+ T cell responses.

Parameter SIV Gag-specific CD8+ T HIV Env-specific CD8+ T
Spearman Correlation a
r p q r p q
D1 DEG
SERPING1 0.2272 0.4123 0.8014 -0.1841 0.5085 0.8460
C3AR1 -0.0966 0.7308 0.9288 -0.3378 0.2170 0.7550
IL1RN 0.0322 0.9106 0.9889 -0.2985 0.2779 0.7550
TNFAIP6 -0.0125 0.9667 0.9911 -0.1341 0.6319 0.8861
PLAUR 0.0575 0.8397 0.9532 0.0518 0.8551 0.9571
FPR2 0.1306 0.6406 0.8881 0.0572 0.8396 0.9532
SOCS3 0.2666 0.3342 0.7741 -0.3146 0.2516 0.7550
OAS1 0.0286 0.9208 0.9911 -0.1528 0.5729 0.8616
TNFSF10 0.1073 0.7019 0.9241 -0.2931 0.2867 0.7550
CCR1 -0.2111 0.4471 0.8274 -0.3682 0.1764 0.7181
LILRA3 0.0859 0.7601 0.9305 -0.0089 0.9771 0.9953
IFITM1 -0.0054 0.9872 0.9953 -0.3450 0.2070 0.7550
ARG2 0.1699 0.5419 0.8463 0.0107 0.9717 0.9934
CD82 0.2039 0.4629 0.8346 -0.0232 0.9363 0.9911
IRF7 -0.0608 0.8296 0.9532 -0.2055 0.4595 0.8341
IFI35 0.1127 0.6875 0.9117 -0.1323 0.6362 0.8872
NFKBIA 0.0376 0.8952 0.9781 -0.0822 0.7700 0.9332
CSF3R -0.0590 0.8346 0.9532 -0.1787 0.5209 0.8463
DDIT3 0.0072 0.9821 0.9953 -0.1430 0.6088 0.8703
GP1BB 0.0877 0.7551 0.9305 0.2752 0.3181 0.7734
CLU 0.2326 0.4012 06852 0.3592 0.1878 0.7393
TNFAIP3 0.0250 0.9309 0.9911 -0.3825 0.1592 0.7180
IL1RL1 0.0125 0.9667 0.9911 -0.1984 0.4756 0.8413
HLA-DMA -0.3757 0.1673 0.1780 0.0214 0.9410 0.9911
KIT 0.0734 0.7946 0.9412 0.2752 0.3181 0.7734
D1 Shared Pathway Genes c
IL2RA -0.0447 0.8749 0.9675 0.1233 0.6598 0.8979
CSF2RB -0.0143 0.9616 0.9911 -0.1930 0.4875 0.8413
FCGR1A -0.0054 0.9872 0.9953 -0.1984 0.4756 0.8413
DUSP4 -0.1002 0.7212 0.9288 -0.1519 0.5865 0.8621
HLA-DQB1 -0.1342 0.6313 0.8861 0.2359 0.3942 0.7988
HLA-DRB1 -0.2701 0.3275 0.7734 -0.2359 0.3942 0.7988
D1 Cytokine Genes d
IFNA2 0.1664 0.5506 0.8477 0.3146 0.2516 0.7550
IL6 0.0572 0.8397 0.9532 0.1215 0.6641 0.8979
IL18 0.1252 0.6546 0.8973 -0.1734 0.5340 0.8463
IFNG 0.2630 0.3409 0.7803 0.2073 0.4552 0.8332
MCP1 -0.0805 0.7748 0.9359 -0.1912 0.4919 0.8413
D1 Cytokine Proteins
IFN-α -0.6440 0.0113 0.3149 0.2431 0.3797 0.7988
IL-6 0.0161 0.9553 0.9911 0.1682 0.5434 0.8463
IL-18 -0.3846 0.1567 0.7180 0.5004 0.0593 0.5055
IFN-γ -0.0877 0.7539 0.9305 0.0734 0.7943 0.9412
MCP-1 0.1360 0.6268 0.8861 -0.0590 0.8350 0.9532
IL-1RA -0.0608 0.8296 0.9532 0.3199 0.2435 0.7550
D3 DEG
CLU -0.0022 0.9969 0.9969 0.1696 0.5596 0.8533
GP1BB -0.1411 0.6281 0.8861 0.1960 0.4989 0.8424
BCL2L1 0.1676 0.5641 0.8567 0.1234 0.6727 0.8997
IL1RL1 0.3462 0.2240 0.7550 0.1256 0.6672 0.8979
ILR2 -0.1147 0.6948 0.9180 -0.0154 0.9607 0.9911
D3 Shared Pathway Genes
HLA-C -0.2272 0.4316 0.8185 0.0771 0.7933 0.9412
FCGR1A 0.3664 0.2170 0.7550 -0.3106 0.2778 0.7550
D3 Cytokine Genes
IFNA2 0.6615 0.0119 0.3149 0.2643 0.3583 0.7988
IL6 0.4851 0.0806 0.6185 0.0793 0.7873 0.9412
IL18 0.6262 0.0189 0.3641 0.3811 0.1785 0.7180
IFNG 0.1610 0.5798 0.8616 0.2137 0.4603 0.8341
MCP1 0.2315 0.4226 0.8055 0.0551 0.8525 0.9571
IL1RN 0.0220 0.9424 0.9911 0.0440 0.8822 0.9726
D3 Cytokine Proteins
IFN-α -0.2666 0.3742 0.7988 0.3200 0.2833 07550
IL-6 0.2851 0.3718 0.7988 0.1051 0.7308 0.9288
IL-18 -0.1004 0.7302 0.9288 0.2183 0.4494 0.8274
IFN-γ 0.2661 0.3538 0.7988 0.1008 0.7279 0.9288
MCP-1 0.1874 0.5180 0.8463 0.3040 0.2885 0.7550
IL-1RA 0.0494 0.8672 0.9618 -0.0141 0.9643 0.9911
a

bold font corresponds to p < 0.05.

b

bold and italic font corresponds to p < 0.01.

c

Genes shared between the top five scoring pathways on D1 also included IL1RN, SOCS3, IFITM1, IRF7, NFKBIA, and KIT, genes that are included in the DEG.

d

The gene encoding IL-1RA is ILRN that is included in the DEG.