TABLE 1.

The biological and morphological features of AD mimic cell model

Cell line	SH‐SY5Y human neuroblastoma cells
Differentiation	Yes (RA and BDNF)
Neuronal marker	GAP43 positive
Tested cell type	Neuron‐like differentiated SH‐SY5Y cells
Stimulus	BDNF decreasing and Aβ peptide 1–42
AD mimic cell model
Morphological feature	Neurite fragmentation
Cell death mode	Caspase−6‐dependent apoptosis and necroptosis
Response to cell death inhibitors
Pan‐caspase inhibitor (Z‐VAD‐FMK, 100 μM)	Inhibited
Caspase−6 inhibitor (Z‐VEID‐FMK, 100 μM)	Inhibited
Necroptosis inhibitor (Necrostatin−1, 20 μM)	Inhibited

Abbreviations: BDNF, brain‐derived neurotrophic factor; GAP43, growth‐associated protein 43; RA, retinoic acid.