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. 2022 Apr 27;13:841759. doi: 10.3389/fimmu.2022.841759

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Copyright © 2022 Ali, Lynch, Khatri, Bamigbola, Chan, Yabuki, Demopulos, Heeney, Pai, Baxendale and Schwaeble

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Complement deposition on the surface of K. pneumoniae and S. aureus is impaired during acute severe COVID-19. A significant reduction in C3b, C4b, and C5b-9 deposition levels on the surface of mucoid K. pneumoniae (A–C) and on the surface of S. aureus (D–F) were detected when using sera from acutely ill patients compared to sera from the same patients taken 3 months after discharge (n = 25) or to control sera ( n= 14). Results were analyzed using 1-way ANOVA, with Dunnett’s correction for multiple comparisons. ****p < 0.0001.