. 2022 Apr 27;9:852012. doi: 10.3389/fnut.2022.852012

Table 8.

Brain tissue mRNA expression in SD rats.

	BDNF	c-fos	c-jun	Nrf2	HO-1	SOD1	SOD2	Bax	Bcl-2	Caspase-3
Normal group	9.15 ± 0.46^d	7.69 ± 0.18^d	6.91 ± 0.40^d	0.87 ± 0.25^a	0.94 ± 0.33^a	10.24 ± 1.04^d	8.86 ± 0.42^d	0.25 ± 0.04^a	6.38 ± 0.24^d	0.17 ± 0.05^a
Lead-induced group	1.00 ± 0.00^a	1.00 ± 0.00^a	1.00 ± 0.00^a	1.00 ± 0.00^a	1.00 ± 0.00^a	1.00 ± 0.00^a	1.00 ± 0.00^a	1.00 ± 0.00^d	1.00 ± 0.00^a	1.00 ± 0.00^d
EDTA group	3.66 ± 0.51^b	2.11 ± 0.16^b	2.97 ± 0.34^b	4.76 ± 0.38^b	3.89 ± 0.57^b	5.56 ± 0.42^b	2.44 ± 0.34^b	0.78 ± 0.16^c	2.73 ± 0.14^b	0.71 ± 0.03^c
L. fermentum SCHY34 group	6.03 ± 0.27^c	5.18 ± 0.19^c	5.17 ± 0.23^c	7.58 ± 0.94^c	6.83 ± 0.45^c	8.68 ± 0.51^c	5.61 ± 0.37^c	0.57 ± 0.07^b	4.68 ± 0.21^c	0.29 ± 0.04^b

Value presented are the mean ± standard deviation (n = 12/group).

^a−d

Mean values with different letters in the same column are significantly different (p < 0.05) according to Duncan's multiple range test. Lead-induced group: Rat free to drink 200 mg/L lead acetate solution every day; EDTA group: Rat free to drink 200 mg/L lead acetate solution every day and treated with 500 mg/kg (b.w) EDTA every day from 8 to 12 week; L. fermentum SCHY34 group: Rat free to drink 200 mg/L lead acetate solution every day and treated with 1.0 ×10⁹ CFU/kg (b.w) of L. fermentum SCHY34 every day.