Table 1. Baseline demographic and clinical participant characteristics.
| Characteristic | Offspring cohort (n = 2,873) | Third Generation cohort (n = 3,951) |
|---|---|---|
| Age, years | 60 ± 9 | 40 ± 9 |
| Women, n (%) | 1,573 (55%) | 2,109 (53%) |
| eGFR, mL/min/1.73m2 | 84 ± 16 | 102 ± 14 |
| CKD, n (%) | 210 (7%) | 10 (0.3%) |
| BMI, kg/m2 | 27.95 ± 5.22 | 26.87 ± 5.55 |
| Fasting glucose, mg/dL | 102.99 ± 24.59 | 95.02 ± 17.9 |
| Systolic blood pressure, mmHg | 126.18 ± 18.54 | 116.69 ± 14.02 |
| Diastolic blood pressure, mmHg | 74.15 ± 9.7 | 75.26 ± 9.63 |
| Total cholesterol, mg/dL | 200.64 ± 36.42 | 188.81 ± 35.46 |
| HDL cholesterol, mg/dL | 54.41 ± 17.2 | 54.41 ± 16.16 |
| DM, n (%) | 280 (10%) | 114 (3%) |
| Hypertension, n (%) | 1242 (43%) | 726 (18%) |
| Current cigarette smoker, n (%) | 362 (13%) | 605 (15%) |
| Cholesterol-lowering medication use, n (%) | 564 (20%) | 341 (9%) |
| Prevalent cardiovascular disease, n (%) | 308 (11%) | 38 (1%) |
Abbreviations: eGFR, estimated glomerular filtration rate; CKD, chronic kidney disease; BMI, body mass index; HDL, high density lipoprotein; DM, diabetes mellitus
All continuous characteristics are presented as mean ± standard deviation. All categorical variables are presented as total n (column %) in that category.