Table 2. Biomarkers associated with eGFR and ΔeGFR in the FHS Offspring and Third Generation cohorts.
| Protein biomarker | Protein biomarker abbreviation | eGFR, Offspring | eGFR, Third Generation | ΔeGFR, Offspring | ΔeGFR, Third Generation | ||||
|---|---|---|---|---|---|---|---|---|---|
| β ± SE | FDR | β ± SE | p-value | β ± SE | FDR | β ± SE | p-value | ||
| Adipsin | -- | -0.09 ± 0.004 | <1E-27 | -0.04 ± 0.002 | <1E-27 | -0.22 ± 0.04 | 7.3E-07 | -0.16 ± 0.03 | 1.2E-06 |
| Alpha-1-microglobulin | A1M | -0.06 ± 0.004 | <1E-27 | -0.02 ± 0.002 | 3.5E-12 | -0.18 ± 0.04 | 1.1E-05 | -0.17 ± 0.03 | 3.6E-08 |
| Beta-2-microglobulin | B2M | -0.10 ± 0.004 | <1E-27 | -0.03 ± 0.002 | <1E-27 | -0.43 ± 0.04 | 9.9E-21 | -0.13 ± 0.03 | 3.7E-05 |
| Cystatin C | -- | -0.10 ± 0.004 | <1E-27 | -0.04 ± 0.003 | <1E-27 | -0.38 ± 0.04 | 6.8E-16 | -0.21 ± 0.03 | 1.8E-10 |
| Epidermal growth factor containing fibulin-like extracellular matrix protein 1 | EFEMP1 | -0.05 ± 0.004 | 1.7E-26 | -0.01 ± 0.003 | 8.7E-4 | -0.17 ± 0.04 | 2.8E-04 | -0.18 ± 0.03 | 1.6E-07 |
| Myoglobin | -- | -0.07 ± 0.004 | <1E-27 | -0.04 ± 0.003 | <1E-27 | -0.20 ± 0.04 | 1.5E-05 | -0.13 ± 0.04 | 3.3E-04 |
| Soluble receptor for advanced glycation endproducts | sRAGE | -0.03 ± 0.004 | 3.0E-14 | -0.01 ± 0.002 | 6.4E-07 | -0.10 ± 0.03 | 0.02 | -0.11 ± 0.03 | 9.4E-05 |
| Tissue inhibitor of metalloproteinases 1 | TIMP1 | -0.06 ± 0.004 | <1E-27 | -0.02 ± 0.002 | 4.4E-16 | -0.21 ± 0.04 | 8.2E-06 | -0.14 ± 0.03 | 4.5E-06 |