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. 2022 May 11;12:7784. doi: 10.1038/s41598-022-11582-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of experimental design and analysis. (a) Visual timeline of experimental animal cohorts and initial number of animals in each cohort. Mice were instrumented with an electrophysiological montage and cannula or only a cannula at least 2 weeks prior to AD-tau seed injections. Mice were subsequently injected at 90 or 180 days after birth with AD-tau or buffer solutions and sacrificed or recorded at different timepoints (m.p.i. refers to months post injection). (b) Histological evaluation of pathology was carried out using brain clearance and immunohistological staining, followed by light-sheet imaging and image segmentation and quantification. (c) Sagittal illustration of the recording montage and analysis pipeline prior to quantitative analysis.