. 2022 May 11;12:7784. doi: 10.1038/s41598-022-11582-1

Table 1.

Table containing the pairwise comparisons of the amount of quantified AT8-positive tau pathology.

Brain Region	Pairwise comparison	Estimate	SE	df	T ratio	P value
(a) Longitudinal comparison of AT8 pathology
Entorhinal area	6mo TG-Tau 1mpi—6mo TG-Tau 3mpi	− 0.0037	0.0010	96	− 3.7452	0.0021
	6mo TG-Tau 1mpi—6mo TG-Tau 5mpi	− 0.0075	0.0011	96	− 6.7372	0.0001
	6mo TG-Tau 3mpi—6mo TG-Tau 5mpi	− 0.0038	0.0011	96	− 3.3899	0.0056
Isocortex	3mo TG-Tau 1mpi—3mo TG-Tau 5mpi	0.0032	0.0011	96	2.9076	0.0216
	6mo TG-Tau 1mpi—6mo TG-Tau 3mpi	− 0.0071	0.0010	96	− 7.0609	0.0001
	6mo TG-Tau 3mpi—6mo TG-Tau 5mpi	− 0.0035	0.0011	96	− 3.1687	0.0106
	6mo TG-Tau 1mpi—6mo TG-Tau 5mpi	− 0.0106	0.0011	96	− 9.4793	0.0000
Hippocampal region	3mo TG-Tau 1mpi—3mo TG-Tau 3mpi	− 0.0033	0.0013	96	− 2.6427	0.0433
	3mo TG-Tau 1mpi—3mo TG-Tau 5mpi	− 0.0042	0.0012	96	− 3.4451	0.0048
	6mo TG-Tau 1mpi—6mo TG-Tau 3mpi	− 0.0065	0.0010	96	− 6.4639	0.0001
	6mo TG-Tau 1mpi—6mo TG-Tau 5mpi	− 0.0049	0.0011	96	− 4.4162	0.0002

Brain region	Pairwise comparison	Estimate	SE	df	T ratio	P value
(b) Genotype comparison of AT8 pathology
Entorhinal area	3mo TG-Tau 5mpi—3mo WT Tau 5mpi	0.0016	0.0010	96	1.5568	0.3969
Entorhinal area	6mo TG-Tau 5mpi—6mo WT Tau 5mpi	0.0069	0.0012	96	5.9365	0.0001
Isocortex	3mo TG-Tau 5mpi—3mo WT Tau 5mpi	0.0035	0.0010	96	3.5311	0.0039
Isocortex	6mo TG-Tau 5mpi—6mo WT Tau 5mpi	0.0106	0.0012	96	9.0844	0.0000
Hippocampal region	3mo TG-Tau 5mpi—3mo WT Tau 5mpi	0.0001	0.0010	96	0.0649	0.9999
Hippocampal region	6mo TG-Tau 5mpi—6mo WT Tau 5mpi	0.0036	0.0012	96	3.0635	0.0143

Brain region	Pairwise comparison	Estimate	SE	df	T ratio	P value
(c) Age comparison of AT8 pathology
Entorhinal area	3mo TG-Tau 3mpi—6mo TG-Tau 3mpi	− 0.0038	0.0010	96	− 3.6673	0.0026
Entorhinal area	3mo TG-Tau 5mpi—6mo TG-Tau 5mpi	− 0.0057	0.0011	96	− 5.1333	0.0000
Isocortex	3mo TG-Tau 3mpi—6mo TG-Tau 3mpi	− 0.0041	0.0010	96	− 3.9257	0.0012
Isocortex	3mo TG-Tau 5mpi—6mo TG-Tau 5mpi	− 0.0072	0.0011	96	− 6.4584	0.0000

Pairwise comparisons between (a) Between timepoints in the same genotype-treatment group, (b) Between genotypes, and (c) Between different age groups. 3mo and 6mo refer to 3- or 6-months old animals. (m.p.i. refers to months post injection). TG refers to APP.PS1 animals, WT refers to wild-type. Tau refers to tau-seeded mice, Buffer refers to phosphate-buffered saline injected mice. SE refers to standard error. Df refers to degrees of freedom. Estimate refers to the estimated difference in value between pairwise comparisons. mo refers to months-old at injection.