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. 2022 May 11;12:7784. doi: 10.1038/s41598-022-11582-1

Table 3.

Table containing the pairwise comparisons of power spectra values immediately before and after tau seeding, as well as longitudinal pairwise power spectra comparisons, and pairwise comparisons of Higuchi fractal dimension scores at different timepoints.

Frequency band Pairwise comparison Estimate SE df T ratio P value
(a) Pre and post injection power spectra comparisons in the Hippocampus
Theta 2 3mo Tg Tau Post—3mo Tg Tau Pre  − 0.5623 0.1628 112  − 3.4548 0.0011
6mo Tg Tau Post—6mo Tg Tau Pre  − 0.5703 0.1680 112  − 3.3953 0.0014
3mo Wt Tau Post—3mo Wt Tau Pre  − 0.6912 0.1653 112  − 4.1829 0.0001
6mo Wt Tau Post—6mo Wt Tau Pre  − 0.4815 0.1615 112  − 2.9815 0.0052
Low gamma 3mo Tg Tau Post—3mo Tg Tau Pre  − 0.8025 0.1518 112  − 5.2869 0.0001
6mo Tg Tau Post—6mo Tg Tau Pre  − 0.6461 0.1567 112  − 4.1240 0.0001
3mo Wt Tau Post—3mo Wt Tau Pre  − 0.7126 0.1541 112  − 4.6240 0.0001
6mo Wt Tau Post—6mo Wt Tau Pre  − 0.6713 0.1506 112  − 4.4568 0.0001
3mo Tg Buffer 1mpi—3mo Tg Tau 1mpi  − 0.0152 0.1407 112  − 0.1082 0.9313
3mo Wt Buffer 1mpi—3mo Wt Tau 1mpi  − 0.2753 0.1318 112  − 2.0888 0.0564
6mo Tg Buffer 1mpi—6mo Tg Tau 1mpi  − 0.0961 0.1336 112  − 0.7190 0.5349
6mo Wt Buffer 1mpi—6mo Wt Tau 1mpi 0.8917 0.2166 112 4.1168 0.0002
High Gamma 3mo Tg Tau Post—3mo Tg Tau Pre  − 0.7348 0.1346 112  − 5.4573 0.0001
6mo Tg Tau Post—6mo Tg Tau Pre  − 0.6687 0.1389 112  − 4.8128 0.0001
3mo Wt Tau Post—3mo Wt Tau Pre  − 0.6818 0.1367 112  − 4.9875 0.0001
6mo Wt Tau Post—6mo Wt Tau Pre  − 0.7082 0.1336 112  − 5.3013 0.0001
3mo Tg Buffer 1mpi—3mo Tg Tau 1mpi 0.0611 0.1325 112 0.4612 0.7169
3mo Wt Buffer 1mpi—3mo Wt Tau 1mpi  − 0.1965 0.1242 112  − 1.5829 0.1715
6mo Tg Buffer 1mpi—6mo Tg Tau 1mpi 0.0004 0.1263 112 0.0034 0.9979
6mo Wt Buffer 1mpi—6mo Wt Tau 1mpi 0.8205 0.1966 112 4.1737 0.0002
High Gamma by region Pairwise comparison Estimate SE df T ratio P value
(b) Longitudinal Power changes
Hippocampus 3mo Tg Buffer 1mpi—3mo Wt Buffer 1mpi  − 0.2015 0.1325 112  − 1.5205 0.1904
3mo Tg Tau 1mpi—3mo Wt Tau 1mpi  − 0.4591 0.1244 112  − 3.6913 0.0009
3mo Tg Buffer 3mpi—3mo Wt Buffer 3mpi  − 0.4311 0.1559 112  − 2.7659 0.0132
3mo Tg Tau 3mpi—3mpi Wt Tau 3mpi  − 0.5416 0.1483 112  − 3.6525 0.0010
3mo Tg Buffer 5mpi—3mo Wt Buffer 5mpi  − 0.4993 0.1594 112  − 3.1320 0.0048
3mo Tg Tau 5mpi—3mo Wt Tau 5mpi  − 0.5213 0.1320 112  − 3.9480 0.0004
6mo Tg Buffer 1mpi—6mo Wt Buffer 1mpi  − 0.7288 0.1954 112  − 3.7289 0.0008
6mo Tg Buffer 3mpi—6mo Wt Buffer 3mpi  − 0.3141 0.1242 112  − 2.5300 0.0239
6mo Tg Buffer 5mpi—6mo Wt Buffer 5mpi  − 0.4374 0.1253 112  − 3.4919 0.0016
Retrosplenial cortex 3mo Wt Buffer 5mo—3mo Wt Tau 5mo 0.4061 0.1338 112 3.0352 0.0063
Low Gamma by region
Retrosplenial cortex 3mo Wt Buffer 5mpi—3mo Wt Tau 5mpi 0.3258 0.1433 112 2.2737 0.0373
(c) Hippocampal fractal dimension scores at 5 mpi
HFD values 6mo Tg Buffer 3mpi—6mo Tg Tau 3mpi 0.0313 0.0139 112 2.2563 0.0409
6mo Tg Buffer 5mpi—6mo Tg Tau 5mpi 0.0364 0.0139 112 2.6142 0.0175
6mo Wt Buffer 5mpi—6mo Wt Tau 5mpi  − 0.0360 0.0137 112  − 2.6322 0.0167

(a) Power spectra band values before and after injection within the same genotype-treatment group, (b) Power spectra changes between genotype-treatment groups across time post injection, and (c) Hippocampal Higuchi Fractal Dimension scores at 3- and 5-months post injection. (m.p.i. refers to months post injection). Pre refers to Pre-injection timepoint. Post refers to 1 day after injection. MEC refers to Medial Entorhinal Cortex, HPC refers to Hippocampal CA1, Tha refers to thalamus, RSC refers to Retrosplenial Cortex. TG refers to APP.PS1 animals, WT refers to wild-type. Tau refers to tau-seeded mice, Buffer refers to phosphate-buffered saline injected mice. SE refers to standard error. Df refers to degrees of freedom. Estimate refers to the estimated difference in value between pairwise comparisons. HFD refers to Higuchi fractal dimension. mo refers to months-old at injection.