Figure 3.

Visualized segmentation images. (A) HCC lesion in T2WI. (B) ROI_whole (green) was manually delineated slice by slice. (C) VOI_whole (green) was automatically constructed, covering the whole tumor. (D) On the bases of VOI_whole, VOI_periphery was made hollow by replacing VOI_whole with a peritumoral 5-mm-thickness zone, and the covering part was erased when encountering liver margin, gall bladder, or large vessels (like the inferior vena cava). (E) VOI_{whole + periphery} was generated from the combination of VOI_whole and VOI_periphery. (F) VOI_interface (yellow) was made by volume of 2-pixel automated dilation based on VOI_whole subtracting volume of 2-pixel shrinkage based on VOI_whole, termed the liver–tumor interface. Please note that one pixel is around 1.2 mm, and then 4-pixel-wide band is approximately 5 mm. (D–F) 2-dimensional view of the VOI_periphery, VOI_{whole + periphery} and VOI_interface, respectively. ROI, region of interest. VOI, volume of interest.