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Total AV1451 in ChP. A) Freesurfer and GMM automatic ChP segmentations for two representative subjects of ADNI3 subjects. AV1451 PET images registered to the high-resolution T1-weighted MRIs show high signal in the ChP. B) Total AV1451 binding to ChP in AD and MCI subjects using Freesurfer (Pink) and GMM (Blue) automatic segmentations. The difference between AD and MCI becomes statistically significant using GMM compared to Freesurfer.
