Table 1. A sample of genes induced as a result of disrupting dIDH2 function in thoraces.
| Gene |
Fold
change (linear) |
Adjusted P value |
Human/yeast
ortholog |
Gene group | Cellular component | Biological process |
| Hsp70Ab (CG18743) | 402.57 | 4.21 × 10−9 | HSPA1A/SSA3 | Heat shock protein 70 chaperone |
Cytosol, nucleus, membrane, cell periphery |
Multiple functions related to protein homeostasis, response to stress |
| Alr (CG12534) | 3.82 | 1.05 × 10−16 | GFER/ERV1 | Sulfur oxidoreductase |
Mitochondrion | Mitochondrial protein homeostasis, flavin adenine dinucleotide binding activity |
| Fdx1 (CG4205) | 2.54 | 0.001743 | FDX2/YAH1 | Oxidoreductase | Mitochondrion | Ferredoxin 1, required for iron-sulfur cluster biogenesis and ecdysteroidogenesis |
| PHGPx (CG12013) | 2.39 | 0.004599 | GPX4/GPX2 | Glutathione peroxidase |
Endomembrane system |
Antioxidant enzyme, prevents lipid peroxidation, response to stress |
| Fer1HCH (CG2216) | 2.30 | 0.002471 | FTH1/none | Ferritin | Cytosol, endomembrane system |
Ferritin 1 heavy chain homolog, major iron storage complex, ferroxidase activity |
| Bcn92 (CG3717) | 1.91 | 0.013529 | LYRM4/ISD11 | Complex I LYR family | Cytosol, mitochondrion |
Part of cysteine desulfurase complex, regulates iron-sulfur cluster assembly |
| Nfs1 (CG12264) | 2.12 | 0.008541 | NFS1/NFS1 | Sulfurtransferase | Cytosol, mitochondrion, nucleus |
Cysteine desulfurase, regulates Fe-S cluster biogenesis |
| Qtzl (CG31864) | 3.03 | 0.025038 | NFS1/NFS1 | Sulfurtransferase | Cytosol, mitochondrion, nucleus |
Paralog of CG12264, cysteine desulfurase, regulates Fe-S cluster biogenesis |
| ImpL3 (CG10160) | 4.09 | 1.88 × 10−20 | LDHA/MDH1 | LDH/MDH superfamily |
Largely cytosolic | Lactate dehydrogenase, catalyzes the interconversion between lactate and pyruvate |