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. 2022 May 11;11:e77019. doi: 10.7554/eLife.77019

Figure 4. Human and mouse mature oligodendrocyte (MOL) subpopulation analysis.

(a) Uniform manifold approximation and projection (UMAP) plot showing five subpopulations of MOL identified upon integrating all human and mouse scRNA-seq datasets. (b) Bubble plot showing the top five subpopulation marker genes. All cells in all clusters also express high levels of known myelin-related marker transcripts (CNP, PLP1, MBP, MAG, CLDN11). (c) Relative proportion of mature oligodendrocyte subpopulations in humans and mice. Note that the MOLs of both species contribute to all subpopulations.

Figure 4—source data 1. Model-based analysis of single-cell transcriptomics (MAST)-calculated marker genes from human and mouse integrated mature oligodendrocyte (MOL) subpopulations.

Figure 4.

Figure 4—figure supplement 1. Gene Ontology (GO) term topics enriched per subpopulation.

Figure 4—figure supplement 1.

GO terms of biological processes (small circles) were grouped as topics (large circles). Colors represent association with mature oligodendrocyte (MOL) clusters displayed in Figure 4. False discovery rate (FDR) < 0.05.