Fig. 7.

Nucleosome position analyses by NoMe-Seq across the IGF-1 in2GHRE of nuclei following M.CviP1 treatment for d21 IUGR and sham-operated mice. Either d21 IUGR mice displayed no nucleosome displacement (A), or a single nucleosome was displaced to the 3′-end of control mice compared with Fig. 4B (B). In d21 sham-operated mice, a single nucleosome was also displaced to the 3′-end compared with control mice but with a smaller nucleosome-depleted region (NDR) (C), demonstrating the effect of anesthesia/surgery alone on nucleosome displacement.