Table 2.

Odds of incident cognitive impairment by imputed depressive symptom time weighted averages adjusted for age, sex, race, cohort, and anti-depressant use (n = 5,098:2,906 CHS and 2,192 HABC participants)

Separate models for each life course period (Primary Analysis)
	Early Adulthood	Mid-life	Late-life
CESD-10	OR (95% CI)	OR (95% CI)	OR (95% CI)
Low (0–3)	ref	ref	ref
Moderate (4–10)	1.59 (1.35, 1.89)	1.33 (1.17, 1.51)	1.34 (1.19, 1.50)
High (10+)	NA*	1.94 (1.16, 3.26)	1.77 (1.42, 2.21)
One model, each life course period adjusted for other periods (Secondary Analysis)
CESD-10	Early Adulthood	Mid-life	Late-life
Low (0–3)	ref	ref	ref
Moderate (4–10)	1.38 (1.14, 1.68)	1.00 (0.85, 1.19)	1.29 (1.14, 1.47)
High (10+)	NA*	1.16 (0.65, 2.06)	1.47 (1.12, 1.93)

^*No participants had imputed young adulthood TWAs in this range.