Table 3.

Model for association of CESD-10 TWAs with composite cognitive function outcome with inclusion of each life course stage age, sex, race, cohort, and anti-depressant use as predictors (45,811 observations, 6,122 [3,930 CHS, 2,192 HABC] participants)

	Early Adulthood β (95% CI)	Mid-life β (95% CI)	Late-life β (95% CI)
Difference in cognition at age 80 versus CESD-10 low (0–3) scores
CESD-10
Moderate (4–10)	0.01 (−0.06, 0.08)	−0.04 (−0.09, 0.02)	−0.10 (−0.12, −0.07)
High (10+)	NA*	−0.28 (−0.55, −0.01)	−0.15 (−0.21, −0.10)
Difference in 10-year change in cognition versus CESD-10 low (0–3) scores
CESD-10
Moderate (4–10)	−0.07 (−0.13, −0.01)	0.08 (0.03,0.13)	−0.17 (−0.20, −0.14)
High (10+)	NA*	−0.07 (−0.29, 0.16)	−0.26 (−0.33, −0.20)

Composite defined as average of Z-scores for DSST and −log(101-3MS).