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Effects of FAs on TLR4/NF-κB signaling and NLRP3/caspase-1/GSDMD signaling in chondrocytes. The relative protein expression of collagen II, TLR4, p-NF-κB, NLRP3, caspase-1, and GSDMD in SW1353 cells treated with various concentrations of PA (a), LA (b), OLA (c), and DHA (d) in the absence or presence of LPS for 24 h. The data are presented as the means ± SD, n = 3. ∗p < 0.05 and ∗∗p < 0.01 versus the CON group; #p < 0.05 and ##p < 0.01 versus the LPS group.
