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. 2022 May 4;2022:3711371. doi: 10.1155/2022/3711371

Figure 7.

Figure 7

TLR4 inhibition attenuated SFA- and n-6 PUFA-mediated activation of NLRP3/caspase-1/GSDMD signaling. The relative protein expression of collagen II, TLR4, p-NF-κB, and IL-1β in SW1353 cells treated with PA (a) or LA (b). The relative protein expression of NLRP3, caspase-1, and GSDMD in SW1353 cells treated with PA (c) or LA (d). Immunofluorescent staining was used to detect the expression of caspase-1 (e, g) and GSDMD (f, h) in SW1353 cells treated with PA or LA (200x, scale bars = 100 μm). The data are presented as the means ± SD, n = 3. ∗p < 0.05 and ∗∗p < 0.01 versus the CON group; #p < 0.05 and ##p < 0.01 versus the groups without CLI-095-pretreatment; ^p < 0.05 and ^^p < 0.01 versus the LPS group; &p < 0.05 and &&p < 0.01 versus the PA or LA group.