Table 1.

Summary of included studies investigating association between breast implant placement and autoimmune/connective tissue disorders.

Author, year	Study type	Patients/studies	Findings
Balk et al. [20], Ann Intern Med., PMID: 26550776	Systematic review	32 studies	Increased risk of RA, Sjogren's syndrome, and Raynaud's in women with breast implants
Coroneos et al. [21], Ann Surg., PMID: 30222598	Retrospective cohort study	99,993 patients, (83317 silicone, 16676 saline)	Increased rates of Sjogren's syndrome, scleroderma, and RA in breast implant patients vs. general population
Khoo et al. [22],, Clin Rheumatol, PMID: 30706290	Retrospective cohort study	30 breast implants vs. 90 SLE or SSc controls	Significantly increased risk for fibromyalgia or CFS against SLE controls
Lee et al. [17], Int J Epidemiology, PMID: 20943932	Prospective cohort study	23847 patients (3950 with breast implants, 19897 controls)	Increased risk for CTDs confirmed with medical records with breast implants
Singh et al. [23], Plast Reconstr Surg, PMID: 28953716	Retrospective cohort study	55,279 breast implants	Increased risk for Sjogren's syndrome, RA, and mixed connective tissue disease, though not statistically significant
Watad et al. [15], Int J Epidemiology, PMID: 30329056	Retrospective cohort study	24652 SBI recipients vs. 98604 controls	Increased risk of having any autoimmune/rheumatic disorder with SBI, with significantly increased risk for Sjogren's syndrome, systemic sclerosis, and sarcoidosis

RA = rheumatoid arthritis; CFS = chronic fatigue syndrome; CTD = connective tissue disorder; SBI = silicone breast implant.