Table 2.

Summary of studies showing improvement of breast implant illness symptoms with explantation.

Author, year	Study type	Patients/studies	Findings
Maijers et al. [2], Neth J Med, PMID: 24394743	Descriptive cohort study	n = 80 women with SBIs and subsequent onset of unexplained symptoms	After explantation, 36/52 (69%) women with systemic symptoms experienced significant reduction in symptoms
Colaris et al. [7], Immunol Res., PMID: 27406737	Comparative study	n = 100 patients diagnosed in 2014 with ASIA	54 patients underwent explantation, of which 27 (50%) experienced improvement of complaints
de Boer et al. [5], Immunol Res., PMID: 27412295	Systematic review	23 studies were analyzed, N = 622 patients who underwent explantation of breast implants	Explantation improved complaints in 469 of 622 (75%) patients. In patients with autoimmune diseases, additional immunosuppressive therapy increased improvement
Lee et al. [36], Plast Reconstr Surg Glob Open, PMID: 32440423	Prospective cohort study	n = 50 patients with BII	Explantation improved or resolved some symptoms in 39 out of 44 patients (78%)
Wee et al. [73], Ann Plast Surg, PMID 32530850	Retrospective cohort study	n = 552 women with SBIs undergoing explantation with post-operative symptom follow-up	Improvement across 11 common symptom domains following removal of breast implants and total capsulectomy
Glicksman et al. [72], Aesthetic Surg J, PMID: 34915566	Prospective cohort study	n = 150 women undergoing explantation of SBIs versus women undergoing mastopexy	Symptoms of BII significantly improved for greater than 6 months in women undergoing explantation of SBI
Katsnelson et al. [39], Plast Reconst Surg Glob Open, PMID 34513545	Retrospective cohort study	n = 248 women with SBIs undergoing explantation	Of 46 women who responded to postoperative symptom follow-up, 96% reported improvement in symptoms