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. 2021 Dec 1;27(3):1676–1682. doi: 10.1038/s41380-021-01380-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Right hippocampal E-field was not related to antidepressant outcomes (t₄₆ = −0.62, p = 0.54). B Right hippocampal neuroplasticity had a relationship with antidepressant outcomes (t₄₆ = −3.12, p = 0.003). C Structural equation modeling showed that right hippocampal neuroplasticity mediated the relationship between right hippocampal E-field strength and antidepressant response. D Right hippocampal E-field was associated with change in DKEFS Letter Fluency (t₄₄ = −2.44, p = 0.02). E Right hippocampal neuroplasticity was not related to change in DKEFS Letter Fluency (t₄₄ = −0.68, p = 0.50). F Structural equation modeling showed that right hippocampal neuroplasticity did not mediate the direct effect of right hippocampal E-field and change in DKEFS Letter Fluency. G Receiver operator characteristic curve analysis comparing right hippocampal E-field and cognitive outcome (change in DKEFS Letter Fluency > −3) revealed an area under the curve of 0.78 (95% CI: 0.64–0.93) and maximal sensitivity and specificity of 112.5 V/m.