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. 2021 Nov 24;27(3):1774–1791. doi: 10.1038/s41380-021-01375-9

Fig. 4. Features contributing to the multi-modal neuropsychosocial signature predicting improvers vs. non-improvers in IBS symptoms after 12 months.

Fig. 4

Absolute loadings depict the relative importance of each feature. Colors represent which group has the maximal mean value for that feature. Component 1 Abbreviations: Morphometry: 9p area 9 posterior (dlPFC), 8BM area 8BM (mPFC), p9-46v area posterior 9-46v (dlPFC). Anatomical Connectivity: 9 m area 9 middle (medial prefrontal cortex [mPFC]), VMV3 ventromedial visual area 1, V3 third visual area, STGa area STGa, Pir Pirform cortex (anterior insula [aINS]), 10d area 10d (OFC), PGs area PGs; TE2p area TE2 posterior Resting-State Functional Connectivity: 6 ma area 6m anterior, 6d dorsal area 6, PHT area PHT, p9-46v area posterior 9-46v, IFSa area IFSa, 25 Area 25 Clinical: ETI total early trauma inventory total score, ETI emotional early trauma inventory emotional subscale score, CMSI 12 months complex multi-symptom inventory in the past 12 months. Component 2: Abbreviations: Morphometry: FOP2 frontal opercular area 2; STGa area STGa Anatomical Connectivity: PFt area Pft; 43 area 43; 6v ventral area 6, d23ab area dorsal 23 a + b, v23ab area ventral dorsal a + b Resting-State Functional Connectivity: MIP medial intraparietal area, Tha Thalamus, FOP2 frontal opercular area 2, 55b area 55b Clinical: pain threshold unpleasantness, pain tolerance unpleasantness; BSQ overall symptoms Bowel Symptom Questionnaire (overall symptom score), BSQ abdominal pain Bowel Symptom Questionnaire (overall abdominal pain).