Table 1.

Top 20 CpGs associated with alcohol consumption in the meta-analysis (N = 8161) along with gene annotations, full gene names, chromosome, and base-pair position of the CpG (Ensembl (v92)).

CpG	Chrom	bp	Gene	Gene name/description	Direction	Z score	p
cg06690548	4	139162808	SLC7A11	Cystine/glutamate transporter	–	−22.06	7.75E–108
cg06088069	14	75895604	JDP2	Jun dimerization protein 2	–	−15.849	1.44E–056
cg06644515	1	173834831	GAS5	Growth arrest-specific 5	–	−14.445	2.71E–047
cg12825509	3	185648568	TRA2B	Transformer-2 protein homolog beta	–	−13.61	3.54E–042
cg11376147	11	57261198	SLC43A1	Large neutral amino acids transporter small subunit 3	–	−13.35	1.18E–040
cg14476101	1	120255992	PHGDH	Phosphoglycerate dehydrogenase	–	−13.34	1.33E–040
cg18120259	6	43894639	LOC100132354		–	−13.226	6.19E–040
cg26457483	1	120256112	PHGDH	Phosphoglycerate dehydrogenase	–	−13.185	1.07E–039
cg12116137	17	1576449	PRPF8	Pre-mRNA-processing-splicing factor 8	++	12.92	3.48E–038
cg03497652	16	4751569	ANKS3	Ankyrin Repeat and Sterile Alpha Motif Domain Containing 3	++	12.49	8.12E–036
cg25124205	6	125519976	TPD52L1	Tumor protein D53	–	−12.187	3.65E–034
cg15837522	8	117892654			–	−12.021	2.74E–033
cg16113793	18	21451607	LAMA3	Laminin subunit alpha 3	++	11.96	5.78E–033
cg01538969	6	30624636	DHX16	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	++	11.731	8.80E–032
cg10254445	1	37197260			–	−11.684	1.54E–031
cg21912872	12	68055270	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2	–	−11.462	2.06E–030
cg08228578	12	57624193	SHMT2	Serine hydroxymethyltransferase	–	−11.428	3.04E–030
cg02711608	19	47287964	SLC1A5	Neutral amino acid transporter B(0)	–	−11.211	3.61E–029
cg12973487	19	1623075	TCF3	Transcription factor 3	++	11.177	5.30E–029
cg01307228	10	90152007	RNLS	Renalase	–	−11.03	2.76E–28