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. 2022 Jan 5;27(3):1839–1847. doi: 10.1038/s41380-021-01416-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Allen Mouse Brain Atlas in situ hybridization of Ttr shows presence largely in the choroid plexus; image credit Allen Institute. B Utilizing the background-subtracted “expression view” demonstrates Ttr expression predominantly in the choroid plexus. C To confirm the findings from the Allen Mouse Brain Atlas exploration, we searched Ttr on DropViz.org, which shows Ttr to be highly expressed in choroid plexus cell-type clusters #12 and #9 with greater than 15,000 transcripts per 100,000 in clusters. The above inquiry was repeated for Folr1 (D–F) and Prlr (G–I), which confirms that these genes Ttr, Folr1, and Prlr are predominantly expressed in the choroid plexus. The DropViz.org plots C, F, and I show the regions across the brain in order from greatest to least expression for the top ten regions.