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. 2022 Jan 5;27(3):1839–1847. doi: 10.1038/s41380-021-01416-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Ttr expression in several Mus musculus brain regions from 129SV/EV (teal) and C57BL/6 (magenta) lines from GEO profile GDS1490. Each point represents a sample. The GDS1490 study shows Ttr to be highly expressed in the choroid plexus tissue, followed by the hippocampus and the cerebellum. B GEO dataset GDS589 of rat brain regions from Sprague Dawley (teal), Wistar (magenta), and Wistar Kyoto (lime) strains shows a wide range of Ttr expression in numerous brain regions, with the highest observed in the ventral striatum. Each point represents a sample. Sprague Dawley and Wistar rats have >40× higher expression of Ttr in the hippocampus compared to Wistar Kyoto rats. C Ttr expression in the temporal cortex from the gray mouse lemur (Microcebus murinus) from GEO dataset GDS4128 shows an enormous range in expression among samples with a young female (teal) and a male (magenta) sample showing several orders higher expression for Ttr compared to the other young male and female samples within the same group. Each point on the plot represents a sample. Finally, D Ttr distribution across 143 GEO profiles shows between-group TTR/Ttr expression differences and that the majority of the studies surveyed show within-dataset expression variability for TTR/Ttr expression.