Table 3.

Patients’ descriptions of the four most commonly reported improvements associated with tirzepatide treatment

Improvement	Selected quotations (gender, age)
Blood glucose	“Yes. Dramatic changes…My sugar usually ran around 150 or higher, and it had gotten down to anywhere between the highest was I think like 125 and the lowest would be usually around 100 to like 105. I think the lowest was 99, I think. And usually my sugars aren't that low.” (F, 56 y) “When I start using the medicine, my sugars came down like crazy… It let me live my life differently. I didn’t have to be worrying about what my sugar was doing to my body because I know that it had the medicine, and the medicine was helping me. So I didn’t have to carry my metformin all the time and I didn’t have to carry the meter all the time. I can just forget about it.” (F, 61 y) “It was great. I didn’t have to worry about overeating or those moments when I just wanted a small piece of candy, I could have a piece of chocolate without being fearful that it would really increase my blood sugar.” (F, 51 y)
Weighta	“I started losing weight really fast. That was like a thrill…And I noticed that my appetite was decreasing which was really good.” (F, 55 y) “My outlook on life was even better. When you feel like you're losing weight, you're noticing it in your clothes, and it just inspires you to do more.” (F, 66 y) “It curtailed my appetite. It brought my weight down about 10–15 pounds. It's a wonderful drug, I'm telling you.” (M, 64 y) “After the first month, I was so happy….Because it really works. Oh my god. It made me lose weight. You know, that was perfect.” (F, 61 y) “I lost weight and I was happy about that... Because I wasn’t able to lose any weight at all before the trial…before the trial, I didn’t have any hope. Felt like I was just a big old person that couldn’t lose any weight... While I was on it, I was losing the weight and I was happy.” (M, 71 y) “Oh my God, finally they made a good medicine for us…It keeps our sugar low…Not only that but it helps us manage our weight...That's awesome. You don't get that from no other medicine as far as I know.” (F, 69 y) “The weight loss was fabulous. I've been on a hundred million diets…When you're diabetic, you really have a very difficult time losing weight. It's very, very difficult. So that is probably why I never could lose weight. And of course diets don’t work.” (F, 55 y) “Once I started this study, I lost another 20 pounds or so and it was so simple. It was like it just melted off. I didn't have nearly as much of an appetite and I was not craving sugars like I had been so that certainly made it simpler to stay lower on my weight and to continue to lose weight.” (M, 65 y)
Appetite	“It suppressed my appetite. I wasn’t that hungry any longer and …when I looked at the food, I didn’t want to eat it… When I started using the medicine, I want to eat because I was hungry, not because I want to eat… It was not because the cake was there and I need to finish the cake.” (F, 61 y) “I think that when I had the loss of appetite, I realized that I could actually control…my sugar better based on what I was actually eating.” (F, 56 y) “I’m not craving food and sweets like I did before especially. Not craving food is great.” (M, 65 y) “My cravings weren't so strong and I could, I could overcome that…A lot of binge eating before the shot. After the shot, I was able to control it better.” (M, 71 y)
Energy	“My body just felt good. There were times when I really felt like I could paint a whole house. So it gave me the energy that I needed to stay independent in my life…There was hope. My biggest thing was hope that I could get my sugar down and I could live with this.” (F, 63 y) “It did a lot for my energy…The more weight I lost, the better I felt.” (M, 52 y) “I didn’t feel sluggish at work. I think I had more energy. I worked a little bit faster.” (F, 56 y) “I felt like doing more things. And that's great because, you know, you feel like living… I had more energy to go outside and work in the garden and do my exercise, and actually do more stuff around the house.” (M, 71 y)

^a The two quotes with the same age and gender (F, 55 y) are from two different individuals