Table 5.

Patients’ reports of impact on quality of life and daily activities with tirzepatide treatment

Areas of impact	Selected quotations (gender, age)
Daily activities	“Let me say it was easier to do some of my activities... cleaning my house, taking the dog for a walk, those sorts of things.” (F, 73 y) “The weight loss has helped me in bending over to pick up things or yard work, my involvement with my grandkids, doing the chores around the house, going down the stairs to do a load of laundry, or just standing. When you've lost weight, you can stand at the sink longer. You can do what you got to do longer.” (M, 64 y) “I can do more things. And I feel less tired… And standing and sitting and folding up clothes and ironing and putting things away and just keeping the house clean, and then doing my gardening. That was a joy for me.” (F, 66 y) “Instead of just doing a few, I'd be able to do ten a day…vacuum the house, mow the yard, sweep up the grass, all that stuff.” (M, 57 y) “With not being so big at work, I felt like I could pick up more stuff. Easier to move around, and just not feel like I was so big I couldn’t do something. I actually wanted to do things.” (F, 56 y) “I was actually saving a lot of time…before I would get out of breath doing certain things, and once the weight started coming off, I was able to do them a little bit quicker. It didn’t take me as long to clean or do laundry.” (F, 51 y)
Exercise	“The weight started coming off so I could exercise longer. I could tolerate standing up, moving around, being more active because of less weight on my knees means less pain, and I can do it longer.” (M, 64 y) “With some of the weight gone, it was a lot easier to lift the weights without feeling out of breath.” (F, 51 y) “I weighed more [before tirzepatide treatment]. I was sluggish. I forced myself to walk and, you know, do my walking…I mean because of the medication, I had more energy, so I didn’t have to force it. It was something I looked forward to doing.” (F, 66 y) “I noticed the more weight I lost, the more energy I felt. I could walk and walk and not get as winded. I actually felt like wanting to exercise.” (F, 52 y)
Participate in leisure activities	“You lose weight and so you're able to do more things. Riding a bike was easier. Roller skating is easier. I have an eight-year-old stepdaughter... So, she's all over the place. And so, it's been easy to keep up with her.” (F, 46 y) “I do dog rescue so actually my interest changed in walking the dogs, because normally I wouldn't want to do that…, so I actually was able to jump in and help walk those dogs…so it was a good impact there.” (F, 52 y) “I do play for the church. I'm a musician. I play for the church and I'm able to do that. And I feel better too. Before all of this, I didn’t have no energy and now I have energy, so I'm happy.” (M, 71 y)
Work	“I've got a part-time job that I work on during weekends. And it's helped me a whole lot with that…it started giving me energy…to pay attention and do what I got to do.” (M, 52 y) “I think I had a little more energy… I work at a hotel. I could clean my rooms faster.” (F, 48 y) “I didn’t feel sluggish at work. I think I had more energy. I worked a little bit faster. Like I didn’t feel like, oh god, I just can't move.” (F, 56 y) “I could work longer, a few more hours through the course of the day, and not be so exhausted.” (F, 67 y) “Absolutely, before I had days where…I couldn't think or function properly and I was very hesitant to go in to work. I deal with a lot of money on my job, and on my job if you mess up, then you have to pay that back, and don't ever want to have to do that, especially when you’re dealing with $20,000–$30,000–$40,000 at a pop…I was so much clearer-headed, and not only anxiety and stress level wise, I felt so much more comfortable that it just helped with all of those things.” (M, 65 y)
Participate in social activities	“If you're good to yourself, you're going to be good to everybody else and you're going to be happier and everybody's going to want to be around you…My social life picked up quite a bit… I started doing more and at work especially I got out of my shell. I've got a lot of friends now because I'm confident.” (M, 52 y) “I would basically isolate myself [before tirzepatide treatment] because most of the time I couldn’t make any events that was going on. I was too afraid to go anywhere and get sick and somebody else having to be responsible to get me back home or to the hospital. [With tirzepatide] I went to a lot of events, and I enjoyed myself. I felt alive again…Just to get out of this house and be with your family and your friends was a blessing… When you have a little bit too much weight and you couldn’t wear that sexy outfit that you wanted to wear…you end up in a moo-moo dress and staying home... With this medication, it gave you a sense of confidence… you could go out there and still have your sexy on.” (F, 63 y) [With tirzepatide] “I was able to say… I’m going to go out and just relax and not have to worry about…I’ve got to come back and check my blood sugar, or let me go to the bathroom and check my blood sugar. I didn't have to do that, so I was able to enjoy those things more freely.” (F, 35 y)