Table 2.

Protein binding of antibiotics

Pharmacokinetics	Protein binding
	High	Low
General	↓ Diffusion, ↓ tissue penetration, ↓ antimicrobial activity	↑ Diffusion, ↑ tissue penetration, ↑ antimicrobial activity
In the critically ill	↑ Diffusion, ↑ tissue penetration, ↑ antimicrobial activity	Unchanged
Examples	Ceftriaxone, doxycycline, ertapenem	Fluoroquinolones, fosfomycin, meropenem

↑ and ↓ indicate increase and decrease, respectively