Table 3.

PK/PD index predictors of efficacy in antibiotics

PK/PD index predictor	PK/PD	Objective	Antibiotics	References
Cmax/MIC	Concentration dependent	Maximize the concentration	Aminoglycosides, fluoroquinolones, ketolides, metronidazole, polymyxin	[29]
T>MIC	Time dependent	Maximize duration of exposure	β-lactams, erythromycin, clarithromycin, linezolid, lincosamides	[30]
AUC0–24/MIC	Concentration dependent with time dependence	Maximize the amount of drug exposure	Azithromycin, clindamycin, linezolid, tetracyclines, daptomycin, fluoroquinolones, aminoglycosides, tigecycline, vancomycin	[31, 32]

AUC_0–24 area under the plasma concentration–time curve from time zero to 24 h, C_max maximum plasma drug concentration, MIC minimum inhibitory concentration, PK/PD pharmacokinetics/pharmacodynamics, T>MIC time above MIC